دورية أكاديمية
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Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort.

التفاصيل البيبلوغرافية
العنوان: Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort.
المؤلفون: Yaskolka Meir A; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA., Wang G; Center On Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Hong X; Center On Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Hu FB; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospitaland, Harvard Medical School, Boston, MA, 02115, USA., Wang X; Center On Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA. xwang82@jhu.edu.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. xwang82@jhu.edu., Liang L; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. lliang@hsph.harvard.edu.
المصدر: BMC medicine [BMC Med] 2024 Sep 11; Vol. 22 (1), pp. 373. Date of Electronic Publication: 2024 Sep 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2003-
مواضيع طبية MeSH: DNA Methylation* , Birth Cohort*, Humans ; Infant, Newborn ; Female ; Male ; Adolescent ; Child ; Infant ; Boston ; Child, Preschool ; Gestational Age ; Body Mass Index ; Body-Weight Trajectory ; Birth Weight ; Overweight/genetics ; Cohort Studies
مستخلص: Background: Gestational age (GEAA) estimated by newborn DNA methylation (GAmAge) is associated with maternal prenatal exposures and immediate birth outcomes. However, the association of GAmAge with long-term overweight or obesity (OWO) trajectories is yet to be determined.
Methods: GAmAge was calculated for 831 children from a US predominantly urban, low-income, multi-ethnic birth cohort based on cord blood DNA methylation profile using Illumina EPIC array. Repeated anthropometric measurements aligned with pediatric primary care schedule allowed us to calculate body-mass-index percentiles (BMIPCT) at specific age and to define long-term weight trajectories from birth to 18 years.
Results: GAmAge was associated with BMIPCT trajectories, defined by 4 groups: stable (consistent OWO: "early OWO"; constant normal weight: "NW") or non-stable (OWO by year 1 of follow-up: "late OWO"; OWO by year 6 of follow-up: "NW to very late OWO"). GAmAge differentiated between the group with consistently normal BMIPCT pattern and the non-stable groups with late and very late OWO development. Such differentiation was observed in the age periods of birth to 1year, 3years, 6years, 10years, and 14years (p < 0.05 for all). The findings persisted after adjusting for GEAA, maternal smoking, delivery method, and child's sex in multivariate models. Birth weight was a mediator for the GAmAge effect on OWO status for specific groups at multiple age periods.
Conclusions: GAmAge is associated with BMIPCT trajectories from birth to age 18 years, independent of GEAA and birth weight. If further confirmed, GAmAge may serve as an early biomarker for predicting BMI trajectory to inform early risk assessment and prevention of OWO.
Trial Registration: ClinicalTrials.gov (NCT03228875).
(© 2024. The Author(s).)
التعليقات: Update of: medRxiv. 2023 Nov 03:2023.11.02.23297965. doi: 10.1101/2023.11.02.23297965. (PMID: 37961472)
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فهرسة مساهمة: Keywords: BMI percentiles; Epigenetic clock; Overweight or obesity; Pediatrics
سلسلة جزيئية: ClinicalTrials.gov NCT03228875
تواريخ الأحداث: Date Created: 20240910 Date Completed: 20240911 Latest Revision: 20240924
رمز التحديث: 20240924
مُعرف محوري في PubMed: PMC11389437
DOI: 10.1186/s12916-024-03568-9
PMID: 39256781
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-7015
DOI:10.1186/s12916-024-03568-9