دورية أكاديمية
Tannic Acid-Based Self-Assembling Nanocarriers with Antiphotobleaching and Controlled Releasing Properties for Collaborative Near-Infrared Photothermal/Photodynamic Therapy.
| العنوان: | Tannic Acid-Based Self-Assembling Nanocarriers with Antiphotobleaching and Controlled Releasing Properties for Collaborative Near-Infrared Photothermal/Photodynamic Therapy. |
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| المؤلفون: | Tian J; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, P. R. China., Feng E; Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Hainan Functional Materials and Molecular Imaging, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, P. R. China., Sun H; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, P. R. China., Hou H; State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, P. R. China., Lv F; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, P. R. China., Shao Y; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, P. R. China., Song F; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, P. R. China. |
| المصدر: | ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Sep 25; Vol. 16 (38), pp. 50335-50343. Date of Electronic Publication: 2024 Sep 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مواضيع طبية MeSH: | Tannins*/chemistry , Tannins*/pharmacology , Photochemotherapy* , Photosensitizing Agents*/chemistry , Photosensitizing Agents*/pharmacology , Nanoparticles*/chemistry , Methylene Blue*/chemistry , Methylene Blue*/pharmacology , Infrared Rays*, Animals ; Mice ; Humans ; Photothermal Therapy ; Drug Carriers/chemistry ; Reactive Oxygen Species/metabolism ; Mice, Inbred BALB C ; Neoplasms/drug therapy ; Neoplasms/therapy ; Neoplasms/pathology ; Cell Line, Tumor ; Polyphenols |
| مستخلص: | Near-infrared (NIR) organic materials have been widely developed for tumor phototherapy due to their deep tumor penetration, good biodegradability, and high photothermal conversion (PCE). However, most of the NIR organic dyes are easily destroyed by photooxidation due to their big and long conjugated structures, such as cyanine dyes. Under light irradiation, the reactive oxygen species (ROS) produced by these NIR dyes can easily break their conjugated skeleton, resulting in a dramatic decrease in phototherapeutic efficiency. Herein, an NIR organic dye cyanine dye (CyS) and a photosensitizer methylene blue (MB) were chosen to prepare nanocarrier CMTNPs by facile self-assembling with a natural antioxidant, tannic acid (TA). TA can greatly enhance the stability of NIR cyanine dyes by scavenging ROS. Furthermore, CMTNPs have a character of pH/thermal dual response, allowing for controlled release of MB in the slightly acidic tumor environment during photothermal therapy. The released MB can turn on both fluorescence and photodynamic therapy effects. In vitro and in vivo experiments demonstrated the remarkable tumor ablation ability of CMTNPs. Thus, our study provided an antiphotobleaching and controlled release photosensitizer strategy through the introduction of antioxidant TA into the nanocarrier for efficient collaborative photothermal/photodynamic therapy. |
| فهرسة مساهمة: | Keywords: antiphotobleaching; cyanine dyes; nanocarrier; photodynamic therapy; photothermal therapy; tannic acid |
| المشرفين على المادة: | 0 (Tannins) 0 (Photosensitizing Agents) T42P99266K (Methylene Blue) 0 (Drug Carriers) 0 (Reactive Oxygen Species) 0 (tannic acid) 0 (Polyphenols) |
| تواريخ الأحداث: | Date Created: 20240912 Date Completed: 20240927 Latest Revision: 20240927 |
| رمز التحديث: | 20240927 |
| DOI: | 10.1021/acsami.4c09975 |
| PMID: | 39264146 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1944-8252 |
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| DOI: | 10.1021/acsami.4c09975 |