دورية أكاديمية
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Evaluation of Efficiency of Liposome-Entrapped Iridium(III) Complexes Inhibiting Tumor Growth In Vitro and In Vivo.

التفاصيل البيبلوغرافية
العنوان: Evaluation of Efficiency of Liposome-Entrapped Iridium(III) Complexes Inhibiting Tumor Growth In Vitro and In Vivo.
المؤلفون: Hu H; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China., Chen J; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China., Zhang F; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China., Sheng Z; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China., Yang Y; Department of Pharmacy, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, PR China., Xie Y; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China., Zhou L; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China., Liu Y; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Sep 26; Vol. 67 (18), pp. 16195-16208. Date of Electronic Publication: 2024 Sep 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington Dc : American Chemical Society
Original Publication: [Easton, Pa.] : American Chemical Society, [c1963-
مواضيع طبية MeSH: Iridium*/chemistry , Iridium*/pharmacology , Liposomes* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Coordination Complexes*/chemistry , Coordination Complexes*/pharmacology , Coordination Complexes*/chemical synthesis , Coordination Complexes*/therapeutic use , Apoptosis*/drug effects, Animals ; Mice ; Cell Line, Tumor ; Humans ; Mice, Inbred C57BL ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/pathology ; Melanoma, Experimental/metabolism ; Membrane Potential, Mitochondrial/drug effects
مستخلص: In this paper, three new iridium(III) complexes: [Ir(piq) 2 (DFIPP)]PF 6 (piq = deprotonated 1-phenylisoquinoline, DFIPP = 3,4-difluoro-2-(1 H -imidazo[4,5- f ][1,10]phenenthrolin-2-yl)phenol, 3a ), [Ir(bzq) 2 (DFIPP)]PF 6 (bzq = deprotonated benzo[ h ]quinoline, 3b ), and [Ir(ppy) 2 (DFIPP)]PF 6 (ppy = deprotonated 1-phenylpyridine, 3c ), were synthesized and characterized. The complexes were found to be nontoxic to tumor cells via 3-(4,5-dimethylthiazole-2-yl)-diphenyltetrazolium bromide (MTT) assay. Surprisingly, its liposome-entrapped complexes 3alip, 3blip, and 3clip on B16 cells showed strong cytotoxicity (IC 50 = 13.6 ± 2.8, 9.6 ± 1.1, and 18.9 ± 2.1 μM). Entry of 3alip, 3blip, and 3clip into B16 cells decreases mitochondrial membrane potential, regulates Bcl-2 family proteins, releases cytochrome c, triggers caspase family cascade reaction, and induces apoptosis. In addition, we also found that 3alip, 3blip, and 3clip triggered ferroptosis and autophagy. In vivo studies demonstrated that 3blip inhibited melanoma growth in C57 mice with a high inhibitory rate of 83.95%, and no organic damage was found in C57 mice.
المشرفين على المادة: 44448S9773 (Iridium)
0 (Liposomes)
0 (Antineoplastic Agents)
0 (Coordination Complexes)
تواريخ الأحداث: Date Created: 20240912 Date Completed: 20240926 Latest Revision: 20240926
رمز التحديث: 20240926
DOI: 10.1021/acs.jmedchem.4c01026
PMID: 39264254
قاعدة البيانات: MEDLINE
الوصف
تدمد:1520-4804
DOI:10.1021/acs.jmedchem.4c01026