دورية أكاديمية
Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania.
| العنوان: | Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania. |
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| المؤلفون: | Ma S; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, Zhejiang 310058, China., Ma Q; Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China., Hu S; Jinhua Institute of Zhejiang University, Jinhua, Zhejiang 321299, China., Mo X; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, Zhejiang 310058, China., Zhu C; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, Zhejiang 310058, China., Zhang X; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, Zhejiang 310058, China., Jia Z; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, Zhejiang 310058, China., Tang L; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, Zhejiang 310058, China., Jiang L; Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China., Cui Y; Department of Neurobiology, Department of Neurology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China., Chen Z; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, Zhejiang 310058, China; Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China., Hu W; Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China. Electronic address: huww@zju.edu.cn., Zhang X; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, Zhejiang 310058, China; Jinhua Institute of Zhejiang University, Jinhua, Zhejiang 321299, China. Electronic address: xiangnan_zhang@zju.edu.cn. |
| المصدر: | Cell reports [Cell Rep] 2024 Sep 24; Vol. 43 (9), pp. 114717. Date of Electronic Publication: 2024 Sep 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| مواضيع طبية MeSH: | Ventral Tegmental Area*/metabolism , Dopaminergic Neurons*/metabolism , Dopaminergic Neurons*/pathology , Receptors, Histamine H2*/metabolism , Receptors, Histamine H2*/genetics , Mania*/metabolism, Animals ; Mice ; Behavior, Animal ; Male ; Mice, Knockout ; Mice, Inbred C57BL ; Receptors, GABA-A/metabolism ; Gene Deletion ; Bipolar Disorder/metabolism ; Bipolar Disorder/pathology ; Bipolar Disorder/genetics |
| مستخلص: | Hyperfunction of the dopamine system has been implicated in manic episodes in bipolar disorders. How dopaminergic neuronal function is regulated in the pathogenesis of mania remains unclear. Histaminergic neurons project dense efferents into the midbrain dopaminergic nuclei. Here, we present mice lacking dopaminergic histamine H2 receptor (H2R) in the ventral tegmental area (VTA) that exhibit a behavioral phenotype mirroring some of the symptoms of mania, including increased locomotor activity and reduced anxiety- and depression-like behavior. These behavioral deficits can be reversed by the mood stabilizers lithium and valproate. H2R deletion in dopaminergic neurons significantly enhances neuronal activity, concurrent with a decrease in the γ-aminobutyric acid (GABA) type A receptor (GABA Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bipolar disorder; CP: Neuroscience; GABA(A) receptors; dopaminergic neuron; histamine H(2) receptor; mania; ventral tegmental area |
| المشرفين على المادة: | 0 (Receptors, Histamine H2) 0 (Receptors, GABA-A) |
| تواريخ الأحداث: | Date Created: 20240912 Date Completed: 20240926 Latest Revision: 20240927 |
| رمز التحديث: | 20240927 |
| DOI: | 10.1016/j.celrep.2024.114717 |
| PMID: | 39264811 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2211-1247 |
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| DOI: | 10.1016/j.celrep.2024.114717 |