دورية أكاديمية
أعرض في EDS

Identification of Novel Independent Correlations between Cellular Components of the Immune System and Strain-Related Indices of Myocardial Dysfunction in CKD Patients and Kidney Transplant Recipients without Established Cardiovascular Disease.

التفاصيل البيبلوغرافية
العنوان: Identification of Novel Independent Correlations between Cellular Components of the Immune System and Strain-Related Indices of Myocardial Dysfunction in CKD Patients and Kidney Transplant Recipients without Established Cardiovascular Disease.
المؤلفون: Duni A; Department of Nephrology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.; Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece., Kitsos A; Department of Nephrology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.; Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece., Bechlioulis A; Second Department of Cardiology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece., Lakkas L; Second Department of Cardiology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece., Markopoulos G; Laboratory of Haematology-Unit of Molecular Biology and Translational Flow Cytometry, University Hospital of Ioannina, 455 00 Ioannina, Greece., Tatsis V; Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece., Koutlas V; Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece., Tzalavra E; Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece., Baxevanos G; Laboratory of Haematology-Unit of Molecular Biology and Translational Flow Cytometry, University Hospital of Ioannina, 455 00 Ioannina, Greece.; Department of Internal Medicine, General Hospital of Ioannina, G. Chatzikosta, 454 45 Ioannina, Greece., Vartholomatos G; Laboratory of Haematology-Unit of Molecular Biology and Translational Flow Cytometry, University Hospital of Ioannina, 455 00 Ioannina, Greece., Mitsis M; Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece., Naka KK; Second Department of Cardiology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece., Dounousi E; Department of Nephrology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.; Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 23; Vol. 25 (17). Date of Electronic Publication: 2024 Aug 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Kidney Transplantation*/adverse effects , Renal Insufficiency, Chronic*/immunology , Monocytes*/metabolism , Monocytes*/immunology, Humans ; Male ; Female ; Middle Aged ; Echocardiography ; Adult ; Lipopolysaccharide Receptors/metabolism ; Cardiovascular Diseases/etiology ; Aged ; Transplant Recipients ; Immune System ; Receptors, IgG/metabolism
مستخلص: The role of immune system components in the development of myocardial remodeling in chronic kidney disease (CKD) and kidney transplantation remains an open question. Our aim was to investigate the associations between immune cell subpopulations in the circulation of CKD patients and kidney transplant recipients (KTRs) with subclinical indices of myocardial performance. We enrolled 44 CKD patients and 38 KTRs without established cardiovascular disease. A selected panel of immune cells was measured by flow cytometry. Classical and novel strain-related indices of ventricular function were measured by speckle-tracking echocardiography at baseline and following dipyridamole infusion. In CKD patients, the left ventricular (LV) relative wall thickness correlated with the CD14++CD16- monocytes (β = 0.447, p = 0.004), while the CD14++CD16+ monocytes were independent correlates of the global radial strain (β = 0.351, p = 0.04). In KTRs, dipyridamole induced changes in global longitudinal strain correlated with CD14++CD16+ monocytes (β = 0.423, p = 0.009) and CD4+ T-cells (β = 0.403, p = 0.01). LV twist and untwist were independently correlated with the CD8+ T-cells (β = 0.405, p = 0.02 and β = -0.367, p = 0.03, respectively) in CKD patients, whereas the CD14++CD16+ monocytes were independent correlates of LV twist and untwist in KTRs (β = 0.405, p = 0.02 and β = -0.367, p = 0.03, respectively). Immune cell subsets independently correlate with left ventricular strain and torsion-related indices in CKD patients and KTRs without established CVD.
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فهرسة مساهمة: Keywords: CD4+ T-cells; CD8+ T-cells; CKD; cardiac remodeling; classical CD14++CD16− monocytes; intermediate CD14++CD16+ monocytes; kidney transplantation; left ventricular strain; natural killer cells; subclinical myocardial dysfunction
المشرفين على المادة: 0 (Lipopolysaccharide Receptors)
0 (Receptors, IgG)
تواريخ الأحداث: Date Created: 20240914 Date Completed: 20240914 Latest Revision: 20240916
رمز التحديث: 20240916
مُعرف محوري في PubMed: PMC11395156
DOI: 10.3390/ijms25179162
PMID: 39273110
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25179162