دورية أكاديمية
أعرض في EDS

Syndecan-1 Plays a Role in the Pathogenesis of Sjögren's Disease by Inducing B-Cell Chemotaxis through CXCL13-Heparan Sulfate Interaction.

التفاصيل البيبلوغرافية
العنوان: Syndecan-1 Plays a Role in the Pathogenesis of Sjögren's Disease by Inducing B-Cell Chemotaxis through CXCL13-Heparan Sulfate Interaction.
المؤلفون: Lee NY; Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu 41405, Republic of Korea., Ture HY; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41405, Republic of Korea., Lee EJ; Laboratory for Arthritis and Bone Biology, Fatima Research Institute, Daegu Fatima Hospital, Daegu 41199, Republic of Korea., Jang JA; Laboratory for Arthritis and Bone Biology, Fatima Research Institute, Daegu Fatima Hospital, Daegu 41199, Republic of Korea., Kim G; Laboratory for Arthritis and Bone Biology, Fatima Research Institute, Daegu Fatima Hospital, Daegu 41199, Republic of Korea., Nam EJ; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41405, Republic of Korea.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 29; Vol. 25 (17). Date of Electronic Publication: 2024 Aug 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Syndecan-1*/metabolism , Chemokine CXCL13*/metabolism , B-Lymphocytes*/metabolism , B-Lymphocytes*/immunology , Sjogren's Syndrome*/metabolism , Sjogren's Syndrome*/pathology , Heparitin Sulfate*/metabolism, Animals ; Mice ; Female ; Mice, Inbred C57BL ; Chemotaxis ; Mice, Inbred NOD ; Submandibular Gland/metabolism ; Submandibular Gland/pathology ; Humans ; Receptors, CXCR5/metabolism ; Protein Binding
مستخلص: In Sjögren's disease (SjD), the salivary glandular epithelial cells can induce the chemotaxis of B cells by secreting B-cell chemokines such as C-X-C motif chemokine ligand 13 (CXCL13). Syndecan-1 (SDC-1) is a major transmembrane heparan sulfate proteoglycan (HSPG) predominantly expressed on epithelial cells that binds to and regulates heparan sulfate (HS)-binding molecules, including chemokines. We aimed to determine whether SDC-1 plays a role in the pathogenesis of SjD by acting on the binding of HS to B-cell chemokines. To assess changes in glandular inflammation and SDC-1 concentrations in the submandibular gland (SMG) and blood, female NOD/ShiLtJ and sex- and age-matched C57BL/10 mice were used. In the SMG of NOD/ShiLtJ mice, inflammatory responses were identified at 8 weeks of age, but increased SDC-1 concentrations in the SMG and blood were observed at 6 weeks of age, when inflammation had not yet started. As the inflammation of the SMG worsened, the SDC-1 concentrations in the SMG and blood increased. The expression of the CXCL13 and its receptor C-X-C chemokine receptor type 5 (CXCR5) began to increase in the SMG at 6 weeks of age and continued until 12 weeks of age. Immunofluorescence staining in SMG tissue and normal murine mammary gland cells confirmed the co-localization of SDC-1 and CXCL13, and SDC-1 formed a complex with CXCL13 in an immunoprecipitation assay. Furthermore, NOD/ShiLtJ mice were treated with 5 mg/kg HS intraperitoneally thrice per week for 6-10 weeks of age, and the therapeutic effects in the SMG were assessed at the end of 10 weeks of age. NOD/ShiLtJ mice treated with HS showed attenuated salivary gland inflammation with reduced B-cell infiltration, germinal center formation and CXCR5 expression. These findings suggest that SDC-1 plays a pivotal role in the pathogenesis of SjD by binding to CXCL13 through the HS chain.
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معلومات مُعتمدة: 2022R1F1A1074842 National Research Foundation of Korea
فهرسة مساهمة: Keywords: B cell; CXCL13; Sjögren’s disease; epithelial cell; syndecan-1
المشرفين على المادة: 0 (Syndecan-1)
0 (Chemokine CXCL13)
9050-30-0 (Heparitin Sulfate)
0 (Cxcl13 protein, mouse)
0 (Sdc1 protein, mouse)
0 (Receptors, CXCR5)
تواريخ الأحداث: Date Created: 20240914 Date Completed: 20240914 Latest Revision: 20240917
رمز التحديث: 20240918
مُعرف محوري في PubMed: PMC11394922
DOI: 10.3390/ijms25179375
PMID: 39273320
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25179375