دورية أكاديمية
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Causal Association between Circulating Metabolites and Dementia: A Mendelian Randomization Study.

التفاصيل البيبلوغرافية
العنوان: Causal Association between Circulating Metabolites and Dementia: A Mendelian Randomization Study.
المؤلفون: Li HM; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Qiu CS; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Du LY; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Tang XL; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Liao DQ; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Xiong ZY; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Lai SM; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Huang HX; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Kuang L; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Zhang BY; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Li ZH; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
المصدر: Nutrients [Nutrients] 2024 Aug 28; Vol. 16 (17). Date of Electronic Publication: 2024 Aug 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Mendelian Randomization Analysis* , Dementia*/blood , Dementia*/genetics , Alzheimer Disease*/blood , Alzheimer Disease*/genetics , Biomarkers*/blood, Humans ; Risk Factors ; Bayes Theorem ; Dementia, Vascular/blood ; Dementia, Vascular/genetics ; Male ; Female
مستخلص: The causal association of circulating metabolites with dementia remains uncertain. We assessed the causal association of circulating metabolites with dementia utilizing Mendelian randomization (MR) methods. We performed univariable MR analysis to evaluate the associations of 486 metabolites with dementia, Alzheimer's disease (AD), and vascular dementia (VaD) risk. For secondary validation, we replicated the analyses using an additional dataset with 123 metabolites. We observed 118 metabolites relevant to the risk of dementia, 59 of which were lipids, supporting the crucial role of lipids in dementia pathogenesis. After Bonferroni adjustment, we identified nine traits of HDL particles as potential causal mediators of dementia. Regarding dementia subtypes, protective effects were observed for epiandrosterone sulfate on AD (OR = 0.60, 95% CI: 0.48-0.75) and glycoproteins on VaD (OR = 0.89, 95% CI: 0.83-0.95). Bayesian model averaging MR (MR-BMA) analysis was further conducted to prioritize the predominant metabolites for dementia risk, which highlighted the mean diameter of HDL particles and the concentration of very large HDL particles as the predominant protective factors against dementia. Moreover, pathway analysis identified 17 significant and 2 shared metabolic pathways. These findings provide support for the identification of promising predictive biomarkers and therapeutic targets for dementia.
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معلومات مُعتمدة: 82204115 National Natural Science Foundation of China; 2021A1515110230 Guangdong Basic and Applied Basic Research Foundation; 2024A04J4571 Science and Technology Program of Guangzhou; SKXRC202408 Youth S&T Talent Support Programme of Guangdong Provincial Association for Science and Technology
فهرسة مساهمة: Keywords: Alzheimer’s disease; Mendelian randomization; dementia; metabolites; vascular dementia
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240914 Date Completed: 20240914 Latest Revision: 20240916
رمز التحديث: 20240916
مُعرف محوري في PubMed: PMC11397200
DOI: 10.3390/nu16172879
PMID: 39275195
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16172879