دورية أكاديمية
Helicobacter pylori and acne vulgaris: is there a relationship?
| العنوان: | Helicobacter pylori and acne vulgaris: is there a relationship? |
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| المؤلفون: | Afify AA; Dermatology, venereology and andrology department, Faculty of medicine, Ain Shams University, Cairo, Egypt. dr.ahmed_abdelfattah1982@yahoo.com., Saleh HMA; Dermatology, venereology and andrology department, Faculty of medicine, Ain Shams University, Cairo, Egypt., Hussein AF; Dermatology, venereology and andrology department, Faculty of medicine, Ain Shams University, Cairo, Egypt. |
| المصدر: | Archives of dermatological research [Arch Dermatol Res] 2024 Sep 14; Vol. 316 (9), pp. 621. Date of Electronic Publication: 2024 Sep 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8000462 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-069X (Electronic) Linking ISSN: 03403696 NLM ISO Abbreviation: Arch Dermatol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer Verlag |
| مواضيع طبية MeSH: | Helicobacter pylori*/isolation & purification , Helicobacter pylori*/immunology , Acne Vulgaris*/microbiology , Acne Vulgaris*/immunology , Helicobacter Infections*/immunology , Helicobacter Infections*/microbiology , Helicobacter Infections*/diagnosis , Helicobacter Infections*/complications , Antibodies, Bacterial*/blood , Antibodies, Bacterial*/immunology , Severity of Illness Index*, Humans ; Male ; Female ; Case-Control Studies ; Adult ; Young Adult ; Feces/microbiology ; Adolescent ; Antigens, Bacterial/immunology ; Antigens, Bacterial/blood ; Middle Aged |
| مستخلص: | Background: Helicobacter pylori (H. pylori) is a gastric Gram-negative, spiral-shaped microaerophilic pathogen. H. pylori may play a potential pathogenic role in extra-intestinal diseases such as hepatobiliary, respiratory, and dermatological disorders. The latter included chronic urticaria, psoriasis and rosacea. The first report in literature on the relationship between H. pylori and acne vulgaris (AV), found association between severe AV and H. pylori infection. There are very limited data in AV patients addressing the impact of H. pylori infection on various severities. In this context, the aim of the present work was to determine the association of H. Pylori infection among AV patients and correlate it with the disease severity. Methods: This case-control study included 45 Patients with AV and 45 age and sex matched healthy volunteers as a control group. H. pylori antigen in stool and serum H. pylori antibody IgG using commercially available ELISA kits was tested in all included subjects. Results: The percentage of participants with a positive H. pylori antigen in stool and positive H. pylori antibody in serum in the whole study population was 35/90 (38. 9%) and 41/90 (45. 6%). On comparing between the percentages of positive H. pylori antigen in stool and positive H. pylori antibody in serum between the patients with AV and healthy controls, a highly statistically significant difference was found between the two groups (P < 0.001, P = 0.006). On comparing between the percentages of positive H. pylori antigen in stool and positive H. pylori antibody in serum in the patients with different grades of acne severity and healthy controls, the rate of positive H. pylori antigen in stool and positive H. pylori Ab in serum was significantly associated with severity of acne comparing with healthy controls (p < 0. 001). Conclusion: The rate of H. pylori infection in patients with AV is high so it may influence the pathogenesis of this skin disease. Patients with severe AV had higher rates of H. pylori antigen in stool and H. pylori antibody in serum as compared to the patients with mild AV and healthy controls. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Helicobacter-pylori-acne-vulgaris-relationship |
| المشرفين على المادة: | 0 (Antibodies, Bacterial) 0 (Antigens, Bacterial) |
| تواريخ الأحداث: | Date Created: 20240914 Date Completed: 20240914 Latest Revision: 20240917 |
| رمز التحديث: | 20240917 |
| مُعرف محوري في PubMed: | PMC11401782 |
| DOI: | 10.1007/s00403-024-03300-w |
| PMID: | 39276224 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-069X |
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| DOI: | 10.1007/s00403-024-03300-w |