دورية أكاديمية
Unraveling wasp sensitization in a patient with systemic mastocytosis by CAP-inhibition assay.
| العنوان: | Unraveling wasp sensitization in a patient with systemic mastocytosis by CAP-inhibition assay. |
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| المؤلفون: | Valero H; Allergy Department, Hospital Universitari Vall d´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Luengo O; Allergy Department, Hospital Universitari Vall d´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.; Allergy Research Unit, Allergy Department, Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Cardona V; Allergy Department, Hospital Universitari Vall d´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.; Allergy Research Unit, Allergy Department, Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Pereira J; Allergy Department, Hospital Universitari Vall d´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Labrador-Horrillo M; Allergy Department, Hospital Universitari Vall d´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.; Allergy Research Unit, Allergy Department, Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain; moises.labrador@vallhebron.cat. |
| المصدر: | Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 2024 Sep 01; Vol. 52 (5), pp. 85-88. Date of Electronic Publication: 2024 Sep 01 (Print Publication: 2024). |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Codon Publications Country of Publication: Singapore NLM ID: 0370073 Publication Model: eCollection Cited Medium: Internet ISSN: 1578-1267 (Electronic) Linking ISSN: 03010546 NLM ISO Abbreviation: Allergol Immunopathol (Madr) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [Singapore] : Codon Publications Original Publication: Madrid : Elsevier España |
| مواضيع طبية MeSH: | Wasp Venoms*/immunology , Mastocytosis, Systemic*/diagnosis , Mastocytosis, Systemic*/immunology , Mastocytosis, Systemic*/complications , Anaphylaxis*/diagnosis , Anaphylaxis*/immunology , Anaphylaxis*/etiology , Insect Bites and Stings*/immunology , Insect Bites and Stings*/diagnosis , Insect Bites and Stings*/complications , Wasps*/immunology , Cross Reactions*/immunology, Humans ; Male ; Animals ; Desensitization, Immunologic/methods ; Allergens/immunology ; Allergens/administration & dosage ; Tryptases/blood ; Immunoglobulin E/immunology ; Immunoglobulin E/blood |
| مستخلص: | Systemic mastocytosis (SM) is a clonal mast cell disorder that can lead to potentially severe anaphylactic reactions. Hymenoptera sting is one of the most frequent triggers of anaphylaxis in these patients, and diagnosis of indolent SM (ISM) without skin involvement (ISMs) is not rare. In this subgroup of patients, venom immunotherapy (VIT) is an effective treatment decreasing subsequent systemic reactions, and lifelong administration is recommended. An individualized diagnosis is necessary to offer the most adequate VIT, and molecular diagnosis (MD) may be useful to discriminate between primary sensitization and cross-reactivity. Nevertheless, other techniques such as ImmunoCAP inhibition assays may be necessary to identify the genuine sensitization to offer the most suitable VIT. We present a male patient with an anaphylactic reaction following several wasp stings. The patient was diagnosed with ISM, and allergy to both Polistes dominula and Vespula sp venom was confirmed. In this scenario, MD did not discriminate between a genuine double sensitization and venom cross-reactivity between both vespids. Thus, CAP-inhibition assay was performed. This case indicated the importance of an accurate diagnosis of hymenoptera venom allergy (HVA). It also highlights the usefulness of CAP-inhibition assays when MD fails to distinguish between genuine double Polistes-Vespula sensitization and cross-reactivity. Competing Interests: The authors declare no potential conflicts of interest with respect to research, authorship, and/or publication of this article. |
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| فهرسة مساهمة: | Keywords: CAP-inhibition; REMA-score; hymenoptera venom allergy; indolent systemic mastocytosis; venom immunotherapy |
| المشرفين على المادة: | 0 (Wasp Venoms) 0 (Allergens) EC 3.4.21.59 (Tryptases) 37341-29-0 (Immunoglobulin E) |
| تواريخ الأحداث: | Date Created: 20240915 Date Completed: 20240915 Latest Revision: 20240915 |
| رمز التحديث: | 20240916 |
| DOI: | 10.15586/aei.v52i5.1142 |
| PMID: | 39278856 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1578-1267 |
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| DOI: | 10.15586/aei.v52i5.1142 |