دورية أكاديمية
أعرض في EDS

Prenatal environmental risk factors for autism spectrum disorder and their potential mechanisms.

التفاصيل البيبلوغرافية
العنوان: Prenatal environmental risk factors for autism spectrum disorder and their potential mechanisms.
المؤلفون: Love C; Child Health Research Unit, Barwon Health, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia., Sominsky L; Child Health Research Unit, Barwon Health, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia., O'Hely M; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia.; Murdoch Children's Research Institute, Parkville, Australia., Berk M; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia., Vuillermin P; Child Health Research Unit, Barwon Health, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia.; Murdoch Children's Research Institute, Parkville, Australia., Dawson SL; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia. samantha.dawson@deakin.edu.au.; Murdoch Children's Research Institute, Parkville, Australia. samantha.dawson@deakin.edu.au.; Food and Mood Centre, Deakin University, Geelong, Australia. samantha.dawson@deakin.edu.au.
المصدر: BMC medicine [BMC Med] 2024 Sep 16; Vol. 22 (1), pp. 393. Date of Electronic Publication: 2024 Sep 16.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2003-
مواضيع طبية MeSH: Autism Spectrum Disorder*/etiology , Autism Spectrum Disorder*/epidemiology , Prenatal Exposure Delayed Effects*, Humans ; Pregnancy ; Risk Factors ; Female ; Environmental Exposure/adverse effects ; Maternal Exposure/adverse effects
مستخلص: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is globally increasing in prevalence. The rise of ASD can be partially attributed to diagnostic expansion and advocacy efforts; however, the interplay between genetic predisposition and modern environmental exposures is likely driving a true increase in incidence. A range of evidence indicates that prenatal exposures are critical. Infection during pregnancy, gestational diabetes, and maternal obesity are established risk factors for ASD. Emerging areas of research include the effects of maternal use of selective serotonin reuptake inhibitors, antibiotics, and exposure to toxicants during pregnancy on brain development and subsequent ASD. The underlying pathways of these risk factors remain uncertain, with varying levels of evidence implicating immune dysregulation, mitochondrial dysfunction, oxidative stress, gut microbiome alterations, and hormonal disruptions. This narrative review assesses the evidence of contributing prenatal environmental factors for ASD and associated mechanisms as potential targets for novel prevention strategies.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Autism; Autism spectrum disorder; Biomarkers; Early life exposures; Epidemiology; Etiology; Mental health; Prenatal factors; Psychiatry
تواريخ الأحداث: Date Created: 20240915 Date Completed: 20240915 Latest Revision: 20240918
رمز التحديث: 20240918
مُعرف محوري في PubMed: PMC11404034
DOI: 10.1186/s12916-024-03617-3
PMID: 39278907
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-7015
DOI:10.1186/s12916-024-03617-3