دورية أكاديمية
أعرض في EDS

The characteristics of cognitive and daily living functions of neurocognitive disorders with delusions in elderly Alzheimer's disease.

التفاصيل البيبلوغرافية
العنوان: The characteristics of cognitive and daily living functions of neurocognitive disorders with delusions in elderly Alzheimer's disease.
المؤلفون: Kim SY; Department of Psychology, Kyungpook National University, Daegu, Republic of South Korea.; Department of Neuropsychiatry, Good Samsun Hospital, Busan, Republic of South Korea., Lee SJ; Department of Psychology, Kyungsung University, Busan, Republic of South Korea.
المصدر: PeerJ [PeerJ] 2024 Sep 13; Vol. 12, pp. e18026. Date of Electronic Publication: 2024 Sep 13 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: PeerJ Inc Country of Publication: United States NLM ID: 101603425 Publication Model: eCollection Cited Medium: Internet ISSN: 2167-8359 (Electronic) Linking ISSN: 21678359 NLM ISO Abbreviation: PeerJ Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Corte Madera, CA : PeerJ Inc.
مواضيع طبية MeSH: Alzheimer Disease*/psychology , Alzheimer Disease*/complications , Delusions*/etiology , Delusions*/psychology , Activities of Daily Living*/psychology , Neuropsychological Tests*, Humans ; Female ; Male ; Aged ; Aged, 80 and over ; Cognition/physiology ; Neurocognitive Disorders/etiology ; Neurocognitive Disorders/psychology ; Neurocognitive Disorders/diagnosis ; Severity of Illness Index
مستخلص: Background: Delusions in neurocognitive disorder due to Alzheimer's disease (AD) worsen patients' cognitive functions and activities of daily living (ADL), increasing caregiver burden and the risk of mortality. AD patients with delusions tend to experience a more rapid decline in cognition and have demonstrated poorer performance on various cognitive function tests. Considering the prognosis of delusion in AD patients, it tends to be more favorable with appropriate treatment. However, there is a lack of neuropsychological research, specifically examining the impact of delusions in AD, characterized by progressive deterioration of cognitive function. This study investigates the impact of delusions on cognitive function and ADL under conditions controlling for disease severity.
Methods: We compared cognitive function and ADL in AD patients aged 65 years or older according to the presence of delusions. To assess longitudinal change, we analyzed data from patients monitored for an average of 15 to 16 months. We assessed cognitive function and ADL using the Seoul Neuropsychological Screening Battery-Second Edition (SNSB-II) and delusions using the Neuropsychiatric Inventory (NPI). We used IBM SPSS Statistics version 25.0 for all statistical analyses. The analysis was not adjusted for multiple comparisons. We investigated how delusions impact cognitive function and ADL, controlling for age, educational level, and disease severity.
Results: The delusions group exhibited poorer immediate recall of verbal memory than the non-delusions group. In the follow-up evaluation, patients who developed delusions had lower baseline cognitive function than those who did not, and their language fluency declined over time. In addition, we found the presence of delusions associated with worse functional impairment in ADL as the disease progressed.
Conclusion: While controlling for the severity of AD, we found no significant negative impacts of delusions on most cognitive functions. Nevertheless, it is noteworthy that the immediate recall of verbal memory and the Controlled Oral Word Association Test (COWAT)_animal sensitively detected the negative impact of delusions. Furthermore, since delusions are associated with worsening ADL, we understand that delusion treatment is important for improving the quality of life for patients and caregivers.
Competing Interests: The authors declare there are no competing interests.
(©2024 Kim and Lee.)
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فهرسة مساهمة: Keywords: Alzheimer’s disease; Cognitive functions; Daily living functions; Delusions; Neurocognitive disorder
تواريخ الأحداث: Date Created: 20240917 Date Completed: 20240917 Latest Revision: 20240918
رمز التحديث: 20240918
مُعرف محوري في PubMed: PMC11404475
DOI: 10.7717/peerj.18026
PMID: 39285920
قاعدة البيانات: MEDLINE
الوصف
تدمد:2167-8359
DOI:10.7717/peerj.18026