دورية أكاديمية
"Comparison between high-flow nasal cannula (HFNC) therapy and noninvasive ventilation (NIV) in children with acute respiratory failure by bronchiolitis: a randomized controlled trial".
| العنوان: | "Comparison between high-flow nasal cannula (HFNC) therapy and noninvasive ventilation (NIV) in children with acute respiratory failure by bronchiolitis: a randomized controlled trial". |
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| المؤلفون: | Santos ACEZ; Pediatric Intensive Care Unit, Hospital Municipal Infantil Menino Jesus, São Paulo, São Paulo, Brazil. anazaroni@gmail.com., Caiado CM; Pediatric Intensive Care Unit, Hospital Municipal Infantil Menino Jesus, São Paulo, São Paulo, Brazil., Lopes AGD; Pediatric Intensive Care Unit, Hospital Municipal Infantil Menino Jesus, São Paulo, São Paulo, Brazil., de França GC; Pediatric Intensive Care Unit, Hospital Municipal Infantil Menino Jesus, São Paulo, São Paulo, Brazil., Eisen AKA; Microbiology Department, Universidade de São Paulo, São Paulo, São Paulo, Brazil., Oliveira DBL; Microbiology Department, Universidade de São Paulo, São Paulo, São Paulo, Brazil.; Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil., de Araujo OR; Pediatric Intensive Care Unit, GRAAC, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil., de Carvalho WB; Pediatric Intensive Care Unit, Instituto da Criança, Universidade de São Paulo, São Paulo, São Paulo, Brazil. |
| المصدر: | BMC pediatrics [BMC Pediatr] 2024 Sep 19; Vol. 24 (1), pp. 595. Date of Electronic Publication: 2024 Sep 19. |
| نوع المنشور: | Comparative Study; Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100967804 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2431 (Electronic) Linking ISSN: 14712431 NLM ISO Abbreviation: BMC Pediatr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Bronchiolitis*/therapy , Bronchiolitis*/complications , Noninvasive Ventilation*/methods , Oxygen Inhalation Therapy*/methods , Respiratory Insufficiency*/therapy , Respiratory Insufficiency*/etiology, Female ; Humans ; Infant ; Male ; Acute Disease ; Brazil ; Cannula ; Length of Stay ; Treatment Outcome |
| مستخلص: | Background: The objective of this study was to compare HFNC therapy to noninvasive ventilation (NIV/BiPAP) in children with bronchiolitis who developed respiratory failure. We hypothesized that HFNC therapy would not be inferior to NIV. Methods: This was a noninferiority open-label randomized single-center clinical trial conducted at a tertiary Brazilian hospital. Children under 2 years of age with no chronic conditions admitted for bronchiolitis that progressed to mild to moderate respiratory distress (Wood-Downes-Férres score < 8) were randomized to either the HFNC group or NIV (BiPAP) group through sealed envelopes. Vital signs, FiO Results: A total of 126 patients were allocated to the NIV group (132 randomized and 6 excluded), and 126 were allocated to the HFNC group (136 randomized and 10 excluded). The median age was 2.5 (1-6) months in the NIV group and 3 (2-7) months in the HFNC group (p = 0,07). RSV was the most common virus isolated in both groups (72% vs. 71.4%, NIV and HFNC, respectively). Thirty-seven patients were intubated in the NIV group and 29 were intubated in the HFNC group (29% vs. 23%, p = 0.25). According to the Farrington-Manning test, with a noninferiority margin of 15%, the difference was 6.3% in favor of HFNC therapy (95% confidence interval: -4.5 to 17.1%, p < 0.0001). There was no significant difference in the PICU LOS or sedation duration. Sedation requirement, hospital LOS and invasive mechanical ventilation duration were lower in the HFNC group. Conclusion: HFNC therapy is noninferior to NIV in infants admitted with mild to moderate respiratory distress caused by bronchiolitis that progresses to respiratory failure. Trial Registration Numbers: U1111-1262-1740; RBR-104z966s. Registered 03/01/2023 (retrospectively registered). ReBEC: https://ensaiosclinicos.gov.br/rg/RBR-104z966s . (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Bronchiolitis; High-flow nasal cannula; Noninvasive ventilation; Respiratory failure |
| تواريخ الأحداث: | Date Created: 20240918 Date Completed: 20240919 Latest Revision: 20240924 |
| رمز التحديث: | 20240925 |
| مُعرف محوري في PubMed: | PMC11412039 |
| DOI: | 10.1186/s12887-024-05058-6 |
| PMID: | 39294604 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2431 |
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| DOI: | 10.1186/s12887-024-05058-6 |