دورية أكاديمية
أعرض في EDS

Electron transfer in the respiratory chain at low salinity.

التفاصيل البيبلوغرافية
العنوان: Electron transfer in the respiratory chain at low salinity.
المؤلفون: Lobez AP; Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden., Wu F; Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden., Di Trani JM; Molecular Medicine program, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, Canada.; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Rubinstein JL; Molecular Medicine program, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, Canada.; Department of Medical Biophysics, The University of Toronto, 101 College Street, Toronto, Ontario, Canada.; Department of Biochemistry, The University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada., Oliveberg M; Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden. mikael@dbb.su.se., Brzezinski P; Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden. peterb@dbb.su.se., Moe A; Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden. agnes.moe@unibe.ch.; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, Bern, Switzerland. agnes.moe@unibe.ch.
المصدر: Nature communications [Nat Commun] 2024 Sep 19; Vol. 15 (1), pp. 8241. Date of Electronic Publication: 2024 Sep 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Saccharomyces cerevisiae*/metabolism , Cryoelectron Microscopy* , Salinity* , Cytochromes c*/chemistry , Cytochromes c*/metabolism , Static Electricity*, Electron Transport ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Kinetics ; Electron Transport Complex IV/chemistry ; Electron Transport Complex IV/metabolism ; Electron Transport Complex III/metabolism ; Electron Transport Complex III/chemistry ; Models, Molecular ; Cardiolipins/chemistry ; Cardiolipins/metabolism
مستخلص: Recent studies have established that cellular electrostatic interactions are more influential than assumed previously. Here, we use cryo-EM and perform steady-state kinetic studies to investigate electrostatic interactions between cytochrome (cyt.) c and the complex (C) III 2 -IV supercomplex from Saccharomyces cerevisiae at low salinity. The kinetic studies show a sharp transition with a Hill coefficient ≥2, which together with the cryo-EM data at 2.4 Å resolution indicate multiple cyt. c molecules bound along the supercomplex surface. Negatively charged loops of CIII 2 subunits Qcr6 and Qcr9 become structured to interact with cyt. c. In addition, the higher resolution allows us to identify water molecules in proton pathways of CIV and, to the best of our knowledge, previously unresolved cardiolipin molecules. In conclusion, the lowered electrostatic screening renders engagement of multiple cyt. c molecules that are directed by electrostatically structured CIII 2 loops to conduct electron transfer between CIII 2 and CIV.
(© 2024. The Author(s).)
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المشرفين على المادة: 9007-43-6 (Cytochromes c)
0 (Saccharomyces cerevisiae Proteins)
EC 1.9.3.1 (Electron Transport Complex IV)
EC 7.1.1.8 (Electron Transport Complex III)
0 (Cardiolipins)
تواريخ الأحداث: Date Created: 20240919 Date Completed: 20240919 Latest Revision: 20240922
رمز التحديث: 20240922
مُعرف محوري في PubMed: PMC11413003
DOI: 10.1038/s41467-024-52475-3
PMID: 39300056
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-52475-3