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Effect of post-traumatic stress disorder on type 2 diabetes and the mediated effect of obesity: a Mendelian randomization study.

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العنوان: Effect of post-traumatic stress disorder on type 2 diabetes and the mediated effect of obesity: a Mendelian randomization study.
المؤلفون: Yu Y; Department of Endocrinology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China., Hu G; Department of Endocrinology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China., Yang X; School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China., Bai S; School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China., Wu J; The Third School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Tong K; The Affiliated Changde Hospital, Hunan University of Chinese Medicine, Changde, Hunan, China., Yu R; Department of Endocrinology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.; School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Sep 05; Vol. 15, pp. 1375068. Date of Electronic Publication: 2024 Sep 05 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Mendelian Randomization Analysis* , Diabetes Mellitus, Type 2*/genetics , Diabetes Mellitus, Type 2*/epidemiology , Diabetes Mellitus, Type 2*/complications , Stress Disorders, Post-Traumatic*/genetics , Stress Disorders, Post-Traumatic*/epidemiology , Obesity*/genetics , Obesity*/complications , Obesity*/epidemiology , Genome-Wide Association Study* , Genetic Predisposition to Disease*, Humans ; Hypertension/genetics ; Hypertension/epidemiology ; Risk Factors
مستخلص: Objective: Whether the role of post-traumatic stress disorder (PTSD) on type 2 diabetes (T2D) is mediated by obesity or other mediating factors is controversial. This study was designed to assess the impact of PTSD on genetic susceptibility to T2D and mediating factors.
Methods: The datasets for PTSD, T2D, obesity, hypertension, hyperlipidemia, smoking status, and alcohol consumption were obtained from genome-wide association studies. Mendelian randomization (MR) was used to assess exposure-outcome causality, and inverse variance weighted was used as the primary tool for MR analysis. MR-Egger intercept, Cochran's Q, and leave-one-out sensitivity analysis were employed to assess horizontal pleiotropy, heterogeneity, and robustness, respectively.
Results: The MR analysis showed that PTSD was associated with increased genetic susceptibility to T2D (OR, 1.036; 95% CI, 1.008-1.064; p = 0.011), obesity (OR, 1.033; 95% CI, 1.016-1.050; p < 0.001), and hypertension (OR, 1.002; 95% CI, 1.000-1.003; p = 0.015), but not not with genetic susceptibility to hyperlipidemia, alcohol consumption, and smoking status ( p ≥ 0.05). Mediated effect analysis showed that PTSD increased genetic susceptibility to T2D by increasing genetic susceptibility to obesity and hypertension, with obesity accounting for 9.51% and hypertension accounting for 2.09%. MR-Egger intercept showed no horizontal pleiotropy ( p ≥ 0.05). Cochran's Q showed no heterogeneity ( p ≥ 0.05). Leave-one-out sensitivity analysis showed that the results were robust.
Conclusion: This MR analysis suggests that PTSD increases the risk of T2D and that this effect is partially mediated by obesity and hypertension. Active prevention and treatment of PTSD can help reduce the risk of T2D.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Yu, Hu, Yang, Bai, Wu, Tong and Yu.)
References: JAMA Psychiatry. 2018 Nov 1;75(11):1189-1198. (PMID: 30090920)
Mt Sinai J Med. 2010 Mar-Apr;77(2):197-213. (PMID: 20309918)
Mol Psychiatry. 2022 Aug;27(8):3150-3163. (PMID: 35477973)
JAMA Psychiatry. 2015 Mar;72(3):203-10. (PMID: 25565410)
Front Public Health. 2022 Jun 30;10:940161. (PMID: 35844889)
Clin Psychol Rev. 2012 Jun;32(4):301-15. (PMID: 22459791)
Front Endocrinol (Lausanne). 2023 Mar 09;14:1118848. (PMID: 36967777)
World Psychiatry. 2019 Oct;18(3):259-269. (PMID: 31496089)
Diabet Med. 1999 May;16(5):373-83. (PMID: 10342336)
Curr Psychiatry Rep. 2016 Feb;18(2):20. (PMID: 26800995)
J Trauma Stress. 2013 Oct;26(5):537-47. (PMID: 24151000)
Endocrine. 2022 Sep;77(3):444-454. (PMID: 35841511)
J Clin Psychiatry. 2015 Oct;76(10):e1253-61. (PMID: 26528647)
Psychosom Med. 2007 Apr;69(3):242-8. (PMID: 17401056)
Genet Epidemiol. 2013 Nov;37(7):658-65. (PMID: 24114802)
Obesity (Silver Spring). 2012 Jan;20(1):200-5. (PMID: 22016096)
BMJ. 2018 Jul 12;362:k601. (PMID: 30002074)
Metabolism. 2015 Aug;64(8):926-33. (PMID: 25982700)
Exp Neurol. 2016 Oct;284(Pt B):220-229. (PMID: 27246996)
Comput Struct Biotechnol J. 2021 Mar 10;19:1759-1785. (PMID: 33897980)
J Psychiatr Res. 2014 Sep;56:158-64. (PMID: 24950602)
Eur J Public Health. 2012 Oct;22(5):658-62. (PMID: 21953061)
J Psychosom Res. 2013 Apr;74(4):340-5. (PMID: 23497837)
Diabetes Care. 2010 Aug;33(8):1771-7. (PMID: 20484134)
Asian J Psychiatr. 2021 Sep;63:102800. (PMID: 34340165)
Obesity (Silver Spring). 2015 Apr;23(4):886-92. (PMID: 25776806)
Psychol Med. 2021 Nov;51(15):2647-2656. (PMID: 32375911)
Psychiatr Q. 2009 Jun;80(2):87-97. (PMID: 19291401)
Nat Genet. 2024 May;56(5):792-808. (PMID: 38637617)
Brain. 2022 Apr 29;145(3):832-842. (PMID: 34791088)
Front Cell Infect Microbiol. 2023 May 02;13:1171517. (PMID: 37201114)
J Psychiatr Res. 2007 Nov;41(9):744-52. (PMID: 16901505)
Nature. 2015 Oct 1;526(7571):68-74. (PMID: 26432245)
Psychosom Med. 2016 May;78(4):465-73. (PMID: 26867081)
Cureus. 2022 Oct 31;14(10):e30919. (PMID: 36465766)
فهرسة مساهمة: Keywords: Mendelian randomization; genetic susceptibility; hypertension; obesity; post-traumatic stress disorder; type 2 diabetes
تواريخ الأحداث: Date Created: 20240920 Date Completed: 20240920 Latest Revision: 20240921
رمز التحديث: 20240921
مُعرف محوري في PubMed: PMC11410705
DOI: 10.3389/fendo.2024.1375068
PMID: 39301319
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2024.1375068