دورية أكاديمية
ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant properties of skin cutaneous melanoma cells.
| العنوان: | ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant properties of skin cutaneous melanoma cells. |
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| المؤلفون: | Li H; Department of Dermatology, Harbin Medical University Cancer Hospital, Harbin, 150081, Heilongjiang, P.R. China., Chen Z; Department of Dermatology, The First Affiliated Hospital of Harbin Medical University, No. 199, Dazhi Street, Nangang District, Harbin, 150001, Heilongjiang, P.R. China., Huang Y; Department of Dermatology, The First Affiliated Hospital of Harbin Medical University, No. 199, Dazhi Street, Nangang District, Harbin, 150001, Heilongjiang, P.R. China., Chen C; Department of Dermatology, The Second Hospital of Harbin, Harbin, 150056, Heilongjiang, P.R. China., Cai L; Department of Dermatology, The First Affiliated Hospital of Harbin Medical University, No. 199, Dazhi Street, Nangang District, Harbin, 150001, Heilongjiang, P.R. China. jeremy145@163.com. |
| المصدر: | Archives of dermatological research [Arch Dermatol Res] 2024 Sep 21; Vol. 316 (9), pp. 634. Date of Electronic Publication: 2024 Sep 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8000462 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-069X (Electronic) Linking ISSN: 03403696 NLM ISO Abbreviation: Arch Dermatol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer Verlag |
| مواضيع طبية MeSH: | Ferroptosis*/genetics , Melanoma*/pathology , Melanoma*/genetics , Melanoma*/metabolism , Skin Neoplasms*/pathology , Skin Neoplasms*/genetics , Skin Neoplasms*/metabolism , Cell Proliferation*/genetics , Gene Expression Regulation, Neoplastic* , Cell Movement*/genetics, Humans ; Cell Line, Tumor ; Amino Acid Transport System y+/metabolism ; Amino Acid Transport System y+/genetics ; Coenzyme A Ligases/metabolism ; Coenzyme A Ligases/genetics ; Melanoma, Cutaneous Malignant ; Neoplasm Invasiveness/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics |
| مستخلص: | Ferroptosis, a key factor in tumor progression, is poorly understood at the molecular level. This study investigates how ELK4 and CHMP6 regulate skin cutaneous melanoma (SKCM) cell proliferation and ferroptosis. Analysis of TCGA data reveals high expression of ELK4 and CHMP6 in SKCM. Overexpression of ELK4 or CHMP6 enhances cell proliferation, invasion, and migration while reducing ROS and Fe2 + levels. It also increases GPX4 and xCT expression and decreases ACSL4 levels in SKCM cells. The opposite effects are observed with ELK4 or CHMP6 knockdown. ELK4 binds to the CHMP6 promoter, promoting CHMP6 transcription. Knockdown of CHMP6 reverses the oncogenic effects of ELK4 overexpression. In conclusion, ELK4 enhances proliferation, invasion, and migration while inhibiting ferroptosis in SKCM cells by upregulating CHMP6 transcription. This study sheds light on the intricate mechanisms involved in SKCM progression and identifies potential therapeutic targets in melanoma treatment. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: CHMP6; ELK4; Ferroptosis; Skin cutaneous melanoma; Transcription |
| المشرفين على المادة: | 0 (Amino Acid Transport System y+) EC 6.2.1.- (Coenzyme A Ligases) 0 (SLC7A11 protein, human) EC 6.2.1.3 (long-chain-fatty-acid-CoA ligase) EC 1.11.1.12 (Phospholipid Hydroperoxide Glutathione Peroxidase) |
| تواريخ الأحداث: | Date Created: 20240921 Date Completed: 20240921 Latest Revision: 20240921 |
| رمز التحديث: | 20240922 |
| DOI: | 10.1007/s00403-024-03367-5 |
| PMID: | 39305302 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-069X |
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| DOI: | 10.1007/s00403-024-03367-5 |