دورية أكاديمية
Screening of the Combined Risk of Genetics and Epidemiology on Infertility Among Indian Men: Synergistic Effect of AZFc Partial Deletions and Habits of Smokeless Chewing Tobacco.
| العنوان: | Screening of the Combined Risk of Genetics and Epidemiology on Infertility Among Indian Men: Synergistic Effect of AZFc Partial Deletions and Habits of Smokeless Chewing Tobacco. |
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| المؤلفون: | Dutta S; Cytogenetics and Genomics Research Unit, Department of Zoology, University of Calcutta, Kolkata, India., Paladhi P; Cytogenetics and Genomics Research Unit, Department of Zoology, University of Calcutta, Kolkata, India., Pal S; Cytogenetics and Genomics Research Unit, Department of Zoology, University of Calcutta, Kolkata, India., Srimani S; Cytogenetics and Genomics Research Unit, Department of Zoology, University of Calcutta, Kolkata, India., Bose G; Institute of Reproductive Medicine (IRM), Salt Lake City, Kolkata, India., Ghosh P; Department of Zoology, Bijoy Krishna Girls' College (Affiliated to University of Calcutta), Howrah, India., Chattopadhyay R; Institute of Reproductive Medicine (IRM), Salt Lake City, Kolkata, India., Ghosh S; Cytogenetics and Genomics Research Unit, Department of Zoology, University of Calcutta, Kolkata, India. |
| المصدر: | American journal of men's health [Am J Mens Health] 2024 Sep-Oct; Vol. 18 (5), pp. 15579883241279195. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications, Inc Country of Publication: United States NLM ID: 101287723 Publication Model: Print Cited Medium: Internet ISSN: 1557-9891 (Electronic) Linking ISSN: 15579883 NLM ISO Abbreviation: Am J Mens Health Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Thousand Oaks, CA : Sage Publications, Inc., 2007- |
| مواضيع طبية MeSH: | Tobacco, Smokeless*/adverse effects , Infertility, Male*/genetics , Chromosomes, Human, Y*/genetics, Humans ; Male ; India ; Adult ; Chromosome Deletion ; Case-Control Studies ; Sex Chromosome Disorders of Sex Development/genetics ; Sex Chromosome Aberrations |
| مستخلص: | The AZFc partial deletions of Y chromosome and lifestyle/epidemiological factors such as the use of smokeless chewing tobacco (SCT) exhibit intriguing variations in their association with male infertility across the population, ethnicity, and genetic background. Here, a pioneering attempt has been made to elucidate the interactions of such deletions with the habits of SCT consumption among the participating individuals, using their large epidemiological data. This screening program was conducted among Bengali-speaking men in West Bengal, India. We screened the prevalence and association of distinct partial deletions (gr/gr, b1/b3, and b2/b3) of the AZFc region using locus-specific sequence-tagged site (STS) markers among 728 case subjects and compared them with 264 ethnicity- and age-matched proven-fertile control men. The recorded epidemiological data of the study group and the outcome of partial deletion analysis were compiled to frame the plausible Gene × Epidemiological factor (G × E) interactions. The gr/gr deletion was reported to be significantly associated with azoospermic ( p = .0015, odds ratio [OR] = 3.413) and oligozoospermic ( p = .0382, OR = 3.012) case subgroups, and b1/b3 deletions were also detected among the infertile persons only. The G × E model revealed that men who carried microdeletions as well as were SCT users had an elevated risk of infertility ( p = .002, OR = 6.38). The study highlights the fact that AZFc partial deletions and SCT, when co-occurred, synergistically increase the risk of infertility among men. This work helps to get more insight into the etiology of male infertility in the light of gene-environmental interaction. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| فهرسة مساهمة: | Keywords: AZFc partial deletion; azoospermia; gene–environment interaction; male infertility; smokeless tobacco |
| SCR Disease Name: | Male sterility due to Y-chromosome deletions |
| تواريخ الأحداث: | Date Created: 20240923 Date Completed: 20240923 Latest Revision: 20240923 |
| رمز التحديث: | 20240923 |
| DOI: | 10.1177/15579883241279195 |
| PMID: | 39311468 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1557-9891 |
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| DOI: | 10.1177/15579883241279195 |