دورية أكاديمية
أعرض في EDS

A case of metachronous triple primary carcinoma complicated with pulmonary tuberculosis: Case report and review.

التفاصيل البيبلوغرافية
العنوان: A case of metachronous triple primary carcinoma complicated with pulmonary tuberculosis: Case report and review.
المؤلفون: Chen Y; Department of Oncology, Suining First People's Hospital, Suining, China., Luo S; Department of Oncology, Suining First People's Hospital, Suining, China., Zheng Q; Department of Respiratory Medicine, Suining First People's Hospital, Suining, China., Yu Q; Department of Pathology, Suining First People's Hospital, Suining, China., Liu C; Department of Oncology, Suining First People's Hospital, Suining, China., Tang R; Department of Oncology, Suining First People's Hospital, Suining, China., Chen F; Department of Oncology, Suining First People's Hospital, Suining, China., Zhang Y; Department of Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
المصدر: Medicine [Medicine (Baltimore)] 2024 Sep 20; Vol. 103 (38), pp. e39638.
نوع المنشور: Journal Article; Case Reports; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Tuberculosis, Pulmonary*/complications , Esophageal Neoplasms*/complications , Esophageal Neoplasms*/therapy , Esophageal Neoplasms*/pathology , Carcinoma, Squamous Cell*/complications , Carcinoma, Squamous Cell*/therapy, Humans ; Male ; Middle Aged ; Neoplasms, Second Primary ; Neoplasms, Multiple Primary/complications ; Neoplasms, Multiple Primary/therapy ; Neoplasms, Multiple Primary/pathology
مستخلص: Rationale: Multiple primary malignant neoplasms with tuberculosis are rare. The interaction between tuberculosis and tumor remains unclear. Moreover, the treatment of multiple primary tumors combined with tuberculosis is relatively complicated. Herein, we report a case of metachronous triple primary carcinoma complicated with pulmonary tuberculosis.
Objective: This report aims to analyze the clinical characteristics of 3 primary tumors combined with tuberculosis. We report the long-term survival of this patient after personalized treatment and this patient have a good quality of life.
Diagnoses and Interventions: A 55-year-old male patient was diagnosed with squamous cell carcinoma of the lower thoracic esophagus (cT4bN1M0 IVA) and received concurrent chemoradiotherapy, followed by 2 cycles consolidate chemotherapy. During the follow-up, he was diagnosed with secondary tuberculosis (TB) and accepted anti-TB treatment. During anti-TB treatment, he was diagnosed with squamous cell carcinoma of the oropharynx (cT1N0M0 I P16(-)), then he received radical radiation therapy. However, within a year, the patient was diagnosed with oral squamous cell carcinoma (cT3N0M0 IIIA). He accepted an individualized chemotherapy with paclitaxel combined with capecitabine. Moreover, immunohistochemistry of the patient's 3 biopsies indicated positive P53 expression.
Outcomes: Since the patient suffered from esophageal cancer, oropharyngeal cancer, and oral floor cancer, no tumor recurrence or metastasis was observed. And he has a good quality of life. Tuberculosis, TP53 mutation, radiotherapy, smoking, and drinking history may be risk factors for multiple primary tumors.
Lessons: The treatment of multiple primary tumors combined with pulmonary tuberculosis is complicated. Individualized treatment allows patients to achieve long-term survival while also having a good quality of life. Limitations in this case: surgery may be an alternative strategy for the patient, but the patient refused surgery.
Competing Interests: The authors have no conflicts of interest to disclose.
(Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
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معلومات مُعتمدة: Sichuan Medical Association of Sichuan Province
تواريخ الأحداث: Date Created: 20240923 Date Completed: 20240923 Latest Revision: 20240926
رمز التحديث: 20240926
مُعرف محوري في PubMed: PMC11419472
DOI: 10.1097/MD.0000000000039638
PMID: 39312323
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-5964
DOI:10.1097/MD.0000000000039638