دورية أكاديمية
Transdiagnostic depression severity and its relationship to global and prefrontal-amygdala structural properties in people with major depression and post-traumatic stress disorder.
| العنوان: | Transdiagnostic depression severity and its relationship to global and prefrontal-amygdala structural properties in people with major depression and post-traumatic stress disorder. |
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| المؤلفون: | Li L; Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Guoxuexiang 37#, Wuhou, Chengdu, 640041, China.; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Guoxuexiang 37#, Wuhou, Chengdu, 640041, China., Jiang J; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Guoxuexiang 37#, Wuhou, Chengdu, 640041, China.; The Third People's Hospital, Yangshijie 19#, Qingyang, Chengdu, 610031, China., Zhong S; West China School of Medicine, Sichuan University, Renminnanlu 16#, Wuhou, Chengdu, 640041, China., Lin J; Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Guoxuexiang 37#, Wuhou, Chengdu, 640041, China., Yao Y; West China School of Medicine, Sichuan University, Renminnanlu 16#, Wuhou, Chengdu, 640041, China., Kemp GJ; Liverpool Magnetic Resonance Imaging Centre and Institute of Life Course and Medical Sciences, University of Liverpool, Foundation Building, Brownlow Hill, Liverpool, L69 7ZX, United Kingdom., Chen Y; Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Guoxuexiang 37#, Wuhou, Chengdu, 640041, China., Gong Q; Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Guoxuexiang 37#, Wuhou, Chengdu, 640041, China.; Department of Radiology, West China Xiamen Hospital of Sichuan University, Jinyuanxilu 699#, Jimei, Xiamen, 361022, China. |
| المصدر: | Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Sep 03; Vol. 34 (9). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Oxford University Press, c1991- |
| مواضيع طبية MeSH: | Depressive Disorder, Major*/diagnostic imaging , Depressive Disorder, Major*/physiopathology , Stress Disorders, Post-Traumatic*/diagnostic imaging , Stress Disorders, Post-Traumatic*/physiopathology , Stress Disorders, Post-Traumatic*/pathology , Prefrontal Cortex*/diagnostic imaging , Prefrontal Cortex*/pathology , Amygdala*/diagnostic imaging , Amygdala*/pathology , Magnetic Resonance Imaging*/methods , Gray Matter*/diagnostic imaging , Gray Matter*/pathology, Humans ; Male ; Female ; Adult ; Cross-Sectional Studies ; Middle Aged ; Neural Pathways/diagnostic imaging ; Neural Pathways/pathology ; Severity of Illness Index ; Young Adult |
| مستخلص: | While some studies have used a transdiagnostic approach to relate depression to metabolic or functional brain alterations, the structural substrate of depression across clinical diagnostic categories is underexplored. In a cross-sectional study of 52 patients with major depressive disorder and 51 with post-traumatic stress disorder, drug-naïve, and spanning mild to severe depression severity, we examined transdiagnostic depressive correlates with regional gray matter volume and the topological properties of gray matter-based networks. Locally, transdiagnostic depression severity correlated positively with gray matter volume in the right middle frontal gyrus and negatively with nodal topological properties of gray matter-based networks in the right amygdala. Globally, transdiagnostic depression severity correlated positively with normalized characteristic path length, a measure implying brain integration ability. Compared with 62 healthy control participants, both major depressive disorder and post-traumatic stress disorder patients showed altered nodal properties in regions of the fronto-limbic-striatal circuit, and global topological organization in major depressive disorder in particular was characterized by decreased integration and segregation. These findings provide evidence for a gray matter-based structural substrate underpinning depression, with the prefrontal-amygdala circuit a potential predictive marker for depressive symptoms across clinical diagnostic categories. (© The Author(s) 2024. Published by Oxford University Press.) |
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| معلومات مُعتمدة: | 82302159 National Natural Science Foundation |
| فهرسة مساهمة: | Keywords: amygdala; depression; magnetic resonance imaging; post-traumatic stress disorder; prefrontal cortex |
| تواريخ الأحداث: | Date Created: 20240924 Date Completed: 20240924 Latest Revision: 20240926 |
| رمز التحديث: | 20240926 |
| مُعرف محوري في PubMed: | PMC11420672 |
| DOI: | 10.1093/cercor/bhae381 |
| PMID: | 39315647 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1460-2199 |
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| DOI: | 10.1093/cercor/bhae381 |