دورية أكاديمية
أعرض في EDS

Comment on, "Expression of decitabine-targeted oncogenes in meningiomas in vivo".

التفاصيل البيبلوغرافية
العنوان: Comment on, "Expression of decitabine-targeted oncogenes in meningiomas in vivo".
المؤلفون: Chellapandian H; Lab in Biotechnology and Biosignal Transduction, Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India., Jeyachandran S; Lab in Biotechnology and Biosignal Transduction, Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India. sivakamavalli.sdc@saveetha.com.
المصدر: Neurosurgical review [Neurosurg Rev] 2024 Sep 25; Vol. 47 (1), pp. 681. Date of Electronic Publication: 2024 Sep 25.
نوع المنشور: Journal Article; Letter
اللغة: English
بيانات الدورية: Publisher: Springer Berlin Heidelberg Country of Publication: Germany NLM ID: 7908181 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-2320 (Electronic) Linking ISSN: 03445607 NLM ISO Abbreviation: Neurosurg Rev Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer Berlin Heidelberg
Original Publication: Berlin : Walter De Gruyter
مواضيع طبية MeSH: Decitabine*/pharmacology , Decitabine*/therapeutic use , Meningioma*/genetics , Meningioma*/drug therapy , Meningioma*/pathology , Meningeal Neoplasms*/genetics , Meningeal Neoplasms*/drug therapy , Meningeal Neoplasms*/pathology , Oncogenes*/genetics, Humans ; Antimetabolites, Antineoplastic/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects
مستخلص: The study by Canisius et al. (2022) explores the expression of decitabine-targeted oncogenes (TRIM58, FAM84B, ELOVL2, DIO3) in meningiomas, aiming to evaluate decitabine's therapeutic potential for high-grade tumors. Using immunohistochemical staining and RT-PCR in over 100 patient samples, the authors found significant correlations between oncogene expression and tumor grade, with elevated ELOVL2 levels being linked to tumor recurrence. This work highlights the role of decitabine in modulating oncogene expression and suggests its potential in treating refractory meningiomas. Despite the robust methodology, limitations such as the small sample size and the lack of comprehensive molecular data were noted. Future research should incorporate larger sample sizes and advanced genomic techniques like RNA sequencing to better understand oncogenic mechanisms. The study emphasizes the need for further in situ analyses of decitabine's efficacy, setting the foundation for future neuro-oncological treatments.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
References: Canisius J, Wagner A, Bunk EC, Spille DC, Stögbauer L, Grauer O, Hess K, Thomas C, Paulus W, Stummer W, Senner V, Brokinkel B (2022) Expression of decitabine-targeted oncogenes in meningiomas in vivo. Neurosurg Rev 45:2767–2775. https://doi.org/10.1007/s10143-022-01789-1. (PMID: 10.1007/s10143-022-01789-1354459109349086)
Prathap L, S PS, K PK SP (2021) Effect of Physical Exercise in Remodeling Telomere length and Cancer Prevention in an Epigenetic Prospect – A systematic review. Biomedical Pharmacol J 14:891–901. (PMID: 10.13005/bpj/2191)
Kampmann M (2020) CRISPR-based functional genomics for neurological disease. Nat Rev Neurol 16:465–480. https://doi.org/10.1038/s41582-020-0373-z. (PMID: 10.1038/s41582-020-0373-z326418617484261)
فهرسة مساهمة: Keywords: Decitabine; Immunohistochemistry; Meningiomas; Oncogenes; Tumor recurrence
المشرفين على المادة: 776B62CQ27 (Decitabine)
0 (Antimetabolites, Antineoplastic)
تواريخ الأحداث: Date Created: 20240924 Date Completed: 20240924 Latest Revision: 20240924
رمز التحديث: 20240925
DOI: 10.1007/s10143-024-02926-8
PMID: 39317826
قاعدة البيانات: MEDLINE
الوصف
تدمد:1437-2320
DOI:10.1007/s10143-024-02926-8