دورية أكاديمية
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Case report: Bullous pemphigoid combined with Sjögren's syndrome complicated by central nervous system infection.

التفاصيل البيبلوغرافية
العنوان: Case report: Bullous pemphigoid combined with Sjögren's syndrome complicated by central nervous system infection.
المؤلفون: Chen XY; Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China., Chen J; Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.; Department of Critical Care Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China., Long KL; Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China., Ding P; Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li R; School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Zhi LJ; Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
المصدر: Frontiers in immunology [Front Immunol] 2024 Sep 10; Vol. 15, pp. 1419054. Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024).
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Pemphigoid, Bullous*/drug therapy , Pemphigoid, Bullous*/diagnosis , Pemphigoid, Bullous*/complications , Pemphigoid, Bullous*/etiology , Sjogren's Syndrome*/complications , Sjogren's Syndrome*/diagnosis , Sjogren's Syndrome*/drug therapy , Sjogren's Syndrome*/immunology , Central Nervous System Infections*/complications , Central Nervous System Infections*/drug therapy , Central Nervous System Infections*/diagnosis, Humans ; Female ; Aged ; Methylprednisolone/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use
مستخلص: Background: Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease in humans, characterized by tense blisters, erosions, urticarial lesions, and itching on normal or erythematous skin. Many autoimmune diseases are considered comorbidities of BP, but clinical case reports of BP complicated by Sjögren's syndrome are very scarce. Furthermore, cases of central nervous system infection secondary to both autoimmune diseases are even rarer.
Case Presentation: We report a 74-year-old woman diagnosed with bullous pemphigoid, who showed relief of active lesions after treatment with methylprednisolone and dupilumab injections. However, she was admitted for pulmonary infection during which she was diagnosed with Sjögren's syndrome (SS). Subsequently, the patient developed altered consciousness, indicating a central nervous system infection. Adjustment of steroid dosage and aggressive antimicrobial therapy led to alleviation of symptoms.
Conclusion: The coexistence of autoimmune subepidermal blistering diseases and SS is rare. The role of SS in the pathogenesis of skin lesions is unclear, and the relationship between these blistering diseases and SS remains elusive. Further research is needed to determine whether there are common pathological mechanisms between the two conditions.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Chen, Chen, Long, Ding, Li and Zhi.)
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فهرسة مساهمة: Keywords: Sjogren’s syndrome; autoimmune diseases; bullous pemphigoid; central nervous system infection; pathological mechanisms
المشرفين على المادة: X4W7ZR7023 (Methylprednisolone)
0 (Antibodies, Monoclonal, Humanized)
تواريخ الأحداث: Date Created: 20240925 Date Completed: 20240925 Latest Revision: 20240926
رمز التحديث: 20240926
مُعرف محوري في PubMed: PMC11420039
DOI: 10.3389/fimmu.2024.1419054
PMID: 39318633
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2024.1419054