دورية أكاديمية
أعرض في EDS

PrEP discontinuation, cycling, and risk: Understanding the dynamic nature of PrEP use among female sex workers in South Africa.

التفاصيل البيبلوغرافية
العنوان: PrEP discontinuation, cycling, and risk: Understanding the dynamic nature of PrEP use among female sex workers in South Africa.
المؤلفون: Shipp LM; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Ryan S; Health Sciences Department, NORC at the University of Chicago, Bethesda, Maryland, United States of America., Comins CA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Mcingana M; TB HIV Care, Cape Town, South Africa., Mulumba N; TB HIV Care, uMgungundlovu, South Africa., Guddera V; TB HIV Care, eThekwini, South Africa., Phetlhu DR; Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa., Hausler H; TB HIV Care, Cape Town, South Africa.; Department of Family Medicine, University of Pretoria, Pretoria, South Africa., Baral SD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Schwartz SR; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
المصدر: PloS one [PLoS One] 2024 Sep 26; Vol. 19 (9), pp. e0310489. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Sex Workers*/statistics & numerical data , Sex Workers*/psychology , HIV Infections*/prevention & control , HIV Infections*/epidemiology , Pre-Exposure Prophylaxis*/statistics & numerical data , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/administration & dosage, Humans ; Female ; South Africa ; Adult ; Young Adult
مستخلص: PrEP cycling among women is thought to be safe when there are distinct "seasons of risk." However, cyclical PrEP use over short periods may be associated with increased risk of HIV acquisition. We aimed to characterize key social ecological factors contributing toward PrEP cycling among female sex workers (FSW) in the context of high HIV risk. Semi-structured, in-depth interviews were conducted with 36 FSW at risk for HIV acquisition and 12 key informant (KI) service providers in eThekwini (Durban), South Africa from January-October 2020. FSW identified key factors driving temporary discontinuation of PrEP including relocation, lack of information on or difficulty coping with side effects, and delays in accessing PrEP. In many cases, FSW were motivated to restart PrEP once barriers were overcome. In contrast, KIs emphasized the importance of individual adherence to PrEP and reliance on personal risk assessments when counselling FSW on cycling decisions. FSW and KI perspectives highlight a disconnect between providers' recommendations on the potential for cyclical use of PrEP during periods of minimal risk and actual drivers among FSW causing temporary PrEP discontinuation. Further interventions supporting safe PrEP cycling are needed to ensure decisions around cycling are deliberate and guided by changes in HIV risk rather than external factors.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Shipp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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المشرفين على المادة: 0 (Anti-HIV Agents)
تواريخ الأحداث: Date Created: 20240926 Date Completed: 20240926 Latest Revision: 20240928
رمز التحديث: 20240928
مُعرف محوري في PubMed: PMC11426525
DOI: 10.1371/journal.pone.0310489
PMID: 39325776
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0310489