دورية أكاديمية
Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Older Veterans: Protocol for a Randomized Controlled Trial.
| العنوان: | Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Older Veterans: Protocol for a Randomized Controlled Trial. |
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| المؤلفون: | Bello MO; Joseph Maxwell Cleland Atlanta Veteran Affairs Medical Center, Decatur, GA, United States., Mammino KM; Joseph Maxwell Cleland Atlanta Veteran Affairs Medical Center, Decatur, GA, United States., Vernon MA; School of Medicine, Emory University, Decatur, GA, United States., Wakeman DG; School of Medicine, Emory University, Decatur, GA, United States., Denmon CA; School of Medicine, Emory University, Decatur, GA, United States., Krishnamurthy LC; Department of Physics and Astronomy, Georgia State University, Atlanta, GA, United States., Krishnamurthy V; School of Medicine, Emory University, Decatur, GA, United States., McGregor KM; Birmingham Veteran Affairs Medical Center, Birmingham, AL, United States., Novak TS; School of Medicine, Emory University, Decatur, GA, United States., Nocera JR; School of Medicine, Emory University, Decatur, GA, United States. |
| المصدر: | JMIR research protocols [JMIR Res Protoc] 2024 Sep 26; Vol. 13, pp. e58316. Date of Electronic Publication: 2024 Sep 26. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: JMIR Publications Country of Publication: Canada NLM ID: 101599504 Publication Model: Electronic Cited Medium: Internet ISSN: 1929-0748 (Electronic) Linking ISSN: 19290748 NLM ISO Abbreviation: JMIR Res Protoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Toronto : JMIR Publications |
| مواضيع طبية MeSH: | Exercise*/physiology , Magnetic Resonance Imaging* , Cerebrovascular Circulation*/physiology , Veterans*, Humans ; Aged ; Aged, 80 and over ; Male ; Female ; Cognition/physiology |
| مستخلص: | Background: Growing health care challenges resulting from a rapidly expanding aging population necessitate examining effective rehabilitation techniques that mitigate age-related comorbidity and improve quality of life. To date, exercise is one of a few proven interventions known to attenuate age-related declines in cognitive and sensorimotor functions critical to sustained independence. Objective: This work aims to implement a multimodal imaging approach to better understand the mechanistic underpinnings of the beneficial exercise-induced adaptations to sedentary older adults' brains and behaviors. Due to the complex cerebral and vascular dynamics that encompass neuroplastic change with aging and exercise, we propose an imaging protocol that will model exercise-induced changes to cerebral perfusion, cerebral vascular reactivity (CVR), and cognitive and sensorimotor task-dependent functional magnetic resonance imaging (fMRI) after prescribed exercise. Methods: Sedentary older adults (aged 65-80 years) were randomly assigned to either a 12-week aerobic-based interval-based cycling intervention or a 12-week balance and stretching intervention. Assessments of cardiovascular fitness used the YMCA submaximal VO Results: Our studies and others show that improved cardiovascular fitness in older adults results in improved outcomes related to physical and cognitive health as well as quality of life. A consistent but unexplained finding in many of these studies is a change in cortical activation patterns during task-based fMRI, which corresponds with improved task performance (cognitive-executive and motor). We hypothesize that the 12-week aerobic exercise intervention will increase basal perfusion and improve CVR through a greater magnitude of reactivity in brain areas susceptible to neural and vascular decline (inferior frontal and motor cortices) in previously sedentary older adults. To differentiate between neural and vascular adaptations in these regions, we will map changes in basal perfusion and CVR over the inferior frontal and the motor cortices-regions we have previously shown to be beneficially altered during fMRI BOLD (blood oxygen level dependent), such as verbal fluency and motor tapping, through improved cardiovascular fitness. Conclusions: Exercise is one of the most impactful interventions for improving physical and cognitive health in aging. This study aims to better understand the mechanistic underpinnings of improved health and function of the cerebrovascular system. If our hypothesis of improved perfusion and cerebrovascular reactivity following a 12-week aerobic exercise intervention is supported, it would add critically important insights into the potential of exercise to improve brain health in aging and could inform exercise prescription for older adults at risk for neurodegenerative disease brought on by cerebrovascular dysfunction. Trial Registration: ClinicalTrials.gov NCT05932069; https://clinicaltrials.gov/study/NCT05932069. International Registered Report Identifier (irrid): DERR1-10.2196/58316. (©Medina Oneyi Bello, Kevin Michael Mammino, Mark Anthony Vernon, Daniel G Wakeman, Chanse Aerius Denmon, Lisa Crystal Krishnamurthy, Venkatagiri Krishnamurthy, Keith Matthew McGregor, Thomas Samuel Novak, Joe Robert Nocera. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 26.09.2024.) |
| فهرسة مساهمة: | Keywords: aerobic exercise; aging; cardiovascular disease; cognitive; cognitive health; elderly; exercise; fMRI; functional magnetic resonance imaging; geriatric; geriatrics; health promotion; older adults; physical health; quality of life; sedentary lifestyle; veterans |
| سلسلة جزيئية: | ClinicalTrials.gov NCT05932069 |
| تواريخ الأحداث: | Date Created: 20240926 Date Completed: 20240926 Latest Revision: 20240926 |
| رمز التحديث: | 20240927 |
| DOI: | 10.2196/58316 |
| PMID: | 39326042 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1929-0748 |
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| DOI: | 10.2196/58316 |