دورية أكاديمية
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Transcriptomic Analysis Reveals Diverse Expression of Scorpion Toxin Genes in Mesobuthus martensii .

التفاصيل البيبلوغرافية
العنوان: Transcriptomic Analysis Reveals Diverse Expression of Scorpion Toxin Genes in Mesobuthus martensii .
المؤلفون: Yang Z; Key Laboratory of Zoological Systematics and Application of Hebei Province, School of Life Sciences, Hebei University, Baoding 071002, China., Wang H; Key Laboratory of Zoological Systematics and Application of Hebei Province, School of Life Sciences, Hebei University, Baoding 071002, China., Zhao Y; Key Laboratory of Zoological Systematics and Application of Hebei Province, School of Life Sciences, Hebei University, Baoding 071002, China., Huang J; Key Laboratory of Zoological Systematics and Application of Hebei Province, School of Life Sciences, Hebei University, Baoding 071002, China., Zhang C; Key Laboratory of Zoological Systematics and Application of Hebei Province, School of Life Sciences, Hebei University, Baoding 071002, China.; Hebei Basic Science Center for Biotic Interaction, Hebei University, Baoding 071002, China., Di Z; Key Laboratory of Zoological Systematics and Application of Hebei Province, School of Life Sciences, Hebei University, Baoding 071002, China.
المصدر: Toxins [Toxins (Basel)] 2024 Sep 18; Vol. 16 (9). Date of Electronic Publication: 2024 Sep 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Scorpions*/genetics , Scorpion Venoms*/genetics , Gene Expression Profiling* , Transcriptome*, Animals ; Animals, Poisonous
مستخلص: Scorpions, an ancient group of venomous invertebrates, have existed for over 430 million years. Their toxins, important for predation and defense, exhibit a variety of biological and pharmacological activities. Research on scorpion toxins has spanned decades. Notably, the toxin genes of Mesobuthus martensii (Scorpiones: Buthidae), a well-known Chinese herbal medicine, have been described at genomic and proteomic levels. However, previous studies primarily focused on the toxin genes expressed in the venom glands, overlooking their expression in multiple tissues. This study analyzed transcriptomes from 14 tissues of M . martensii . Gene annotation revealed 83 toxin and toxin-like genes, including those affecting sodium, potassium, calcium, and chloride ion channels. Approximately 70% of toxin genes were highly expressed in the vesicle; additionally, some exhibited low or no expression in the vesicle while showing high expression in other tissues. Beyond the vesicle, high expression levels of toxin genes were observed in metasoma segments II-V, blood, lateral eyes, chelicerae, legs, pedipalp chelae, femurs, and patellae. This expression pattern suggests that toxin genes are recruited from multiple tissues and may help prevent intraspecific harm during courtship and competition for prey. These findings inspire further research into the evolutionary recruitment process of scorpion toxins.
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معلومات مُعتمدة: Hebei Provincial Natural Science Foundation (C2019201273); Advanced Talents Incubation Program of Hebei University (801260201276) Zhiyong Di
فهرسة مساهمة: Keywords: Mesobuthus martensii; scorpion; toxins; transcriptome
المشرفين على المادة: 0 (Scorpion Venoms)
SCR Organism: Mesobuthus martensii
تواريخ الأحداث: Date Created: 20240927 Date Completed: 20240927 Latest Revision: 20240928
رمز التحديث: 20240928
DOI: 10.3390/toxins16090399
PMID: 39330857
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6651
DOI:10.3390/toxins16090399