دورية أكاديمية
Qili Qiangxin capsule attenuates myocardial fibrosis by modulating collagen homeostasis post-infarction in rats.
| العنوان: | Qili Qiangxin capsule attenuates myocardial fibrosis by modulating collagen homeostasis post-infarction in rats. |
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| المؤلفون: | Sun M; Top Discipline of Jiangxi Province, Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Liu C; Top Discipline of Jiangxi Province, Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Gao K; Top Discipline of Jiangxi Province, Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Xu X; Top Discipline of Jiangxi Province, Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Chen K; Top Discipline of Jiangxi Province, Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Qiu L; Top Discipline of Jiangxi Province, Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.; Key Laboratory of Chinese Medicine for Prevention and Treatment of Vascular Remodeling Related Diseases, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Wang X; Top Discipline of Jiangxi Province, Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. |
| المصدر: | PloS one [PLoS One] 2024 Sep 27; Vol. 19 (9), pp. e0310897. Date of Electronic Publication: 2024 Sep 27 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use , Myocardial Infarction*/drug therapy , Myocardial Infarction*/metabolism , Myocardial Infarction*/pathology , Collagen*/metabolism , Fibrosis* , Homeostasis*/drug effects , Rats, Sprague-Dawley* , Ventricular Remodeling*/drug effects , Myocardium*/metabolism , Myocardium*/pathology, Animals ; Rats ; Male ; Matrix Metalloproteinase 9/metabolism ; Capsules ; Tissue Inhibitor of Metalloproteinase-1/metabolism |
| مستخلص: | Myocardial fibrosis (MF) is a major cause of morbidity and mortality worldwide. Qili Qiangxin capsule (QLQX) is a traditional Chinese medicine (TCM) formula used for treating MF, QLQX can affect ventricular remodeling by regulating collagen deposition; however, the specific mechanism by which QLQX modulates collagen homeostasis remains unclear. Thus, this study aimed to explore the effect of QLQX on collagen fibers and its mechanism of action in rats after myocardial infarction (MI). Rats were subjected to left anterior descending artery ligation and then were divided equally into five groups: sham, model, low-dose QLQX, high-dose QLQX and empagliflozin groups. QLQX treatment for 28 days significantly improved cardiac function, as evidenced by decreases in heart mass index, cardiac volume, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, N-terminal B-type natriuretic peptide levels, and high-sensitivity cardiac troponin I levels and increases in left ventricular ejection fraction and left ventricular fraction shortening. Hematoxylin and eosin, Masson, and Picrosirius red staining under a light microscope indicated that QLQX treatment suppressed fibrosis and promoted angiogenesis by decreasing the protein expression levels of proteins related to cardiac remodeling including transforming growth factor-β1, metalloproteinase-9 and α-smooth muscle actin and increasing the expression of tissue inhibitor of matrix metalloproteinase-1 concentration. Picrosirius red staining under the polarized light microscope and western blotting showed that MI increased the contents of collagen I and III, and reduced the contents of collagen II and IV. QLQX treatment improved cardiac function and attenuated MF by modulating collagen homeostasis and promoting angiogenesis. This study provides novel insights into the mechanism of action of QLQX in preventing MF after MI. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2024 Sun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
| المشرفين على المادة: | 0 (Drugs, Chinese Herbal) 0 (qiliqiangxin) 9007-34-5 (Collagen) EC 3.4.24.35 (Matrix Metalloproteinase 9) 0 (Capsules) 0 (Tissue Inhibitor of Metalloproteinase-1) |
| تواريخ الأحداث: | Date Created: 20240927 Date Completed: 20240927 Latest Revision: 20240927 |
| رمز التحديث: | 20240928 |
| DOI: | 10.1371/journal.pone.0310897 |
| PMID: | 39331597 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0310897 |