دورية أكاديمية
The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture.
| العنوان: | The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture. |
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| المؤلفون: | Halpern BC, Clark BR, Hardy DN, Halpern RM, Smith RA |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1974 Apr; Vol. 71 (4), pp. 1133-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Carcinoma 256, Walker/*metabolism , Cells, Cultured/*metabolism , Homocystine/*metabolism , Methionine/*metabolism, Animals ; Breast ; Cell Division/drug effects ; Cell Line ; Cell Survival ; Culture Media ; Female ; Fibroblasts ; Folic Acid/metabolism ; Humans ; Leukemia L1210 ; Leukemia, Experimental ; Leukemia, Myeloid ; Liver ; Male ; Mice ; Prostate ; Rats ; Vitamin B 12/metabolism |
| مستخلص: | In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die. |
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| المشرفين على المادة: | 0 (Culture Media) 462-10-2 (Homocystine) 935E97BOY8 (Folic Acid) AE28F7PNPL (Methionine) P6YC3EG204 (Vitamin B 12) |
| تواريخ الأحداث: | Date Created: 19740401 Date Completed: 19740731 Latest Revision: 20190501 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC388177 |
| DOI: | 10.1073/pnas.71.4.1133 |
| PMID: | 4524624 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0027-8424 |
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| DOI: | 10.1073/pnas.71.4.1133 |