دورية أكاديمية
Mechanism responsible for the cardiovascular depressant. Effect of protamine sulfate.
| العنوان: | Mechanism responsible for the cardiovascular depressant. Effect of protamine sulfate. |
|---|---|
| المؤلفون: | Fadali MA, Ledbetter M, Papacostas CA, Duke LJ, Lemole GM |
| المصدر: | Annals of surgery [Ann Surg] 1974 Aug; Vol. 180 (2), pp. 232-5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0372354 Publication Model: Print Cited Medium: Print ISSN: 0003-4932 (Print) Linking ISSN: 00034932 NLM ISO Abbreviation: Ann Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : Lippincott Williams & Wilkins |
| مواضيع طبية MeSH: | Heart/*drug effects , Protamines/*pharmacology, Animals ; Atropine/pharmacology ; Blood Pressure/drug effects ; Bradycardia/chemically induced ; Cardiac Output/drug effects ; Central Venous Pressure/drug effects ; Dogs ; Extracorporeal Circulation ; Heart Ventricles/drug effects ; Heparin/pharmacology ; Hexamethonium Compounds/pharmacology ; Hypotension/chemically induced ; Phenoxybenzamine/pharmacology ; Propranolol/pharmacology ; Protamines/adverse effects ; Ventricular Function ; p-Methoxy-N-methylphenethylamine/pharmacology |
| مستخلص: | The mechanism of protamine-induced hypotension and bradycardia was investigated in anesthetized, heparinized dogs. Several groups of animals with intact circulation were studied for their responses to protamine under control conditions and following the administration of various pharmacological agents. The parameters observed include femoral arterial pressure (FAP), central venous pressure (CVP), left ventricular pressure (LVP) and its rate of rise (dp/dt), left ventricular contractile element velocity of shortening (Vce), maximal Vce (V max) and cardiac output (CO). Various groups were studied under the following pharmacological conditions: autonomic cholinergic blockade by atropine; alpha and beta adrenergic receptor blockade using phenoxybenzamine and propranolol respectively; ganglionic and adrenal medullary block using hexamethonium, and depletion of endogenous histamine by means of compound 48/80. Another group was placed on total cardiopulmonary bypass thus isolating the heart from the peripheral circulation. The effect of protamine on the vascular tree alone was then observed by monitoring FAP before and after protamine administration. The findings indicate that the cardiovascular effects of protamine are produced by a direct effect on the myocardium and vascular tree. |
| References: | Acta Physiol Acad Sci Hung. 1964;24:365-71. (PMID: 14159894) Lancet. 1961 Sep 16;2(7203):635-7. (PMID: 13725907) Ann Thorac Surg. 1969 May;7(5):459-71. (PMID: 5779755) J Thorac Cardiovasc Surg. 1971 Jan;61(1):160-6. (PMID: 5540459) Br J Pharmacol Chemother. 1951 Sep;6(3):499-508. (PMID: 14878986) Arch Int Pharmacodyn Ther. 1959 Jul 1;120:353-62. (PMID: 14430243) J Thorac Surg. 1956 Nov;32(5):612-9. (PMID: 13368239) Am J Cardiol. 1970 Sep;26(3):248-57. (PMID: 5505450) J Thorac Cardiovasc Surg. 1971 Aug;62(2):193-204. (PMID: 5560501) |
| المشرفين على المادة: | 0 (Hexamethonium Compounds) 0 (Protamines) 0TTZ664R7Z (Phenoxybenzamine) 4091-50-3 (p-Methoxy-N-methylphenethylamine) 7C0697DR9I (Atropine) 9005-49-6 (Heparin) 9Y8NXQ24VQ (Propranolol) |
| تواريخ الأحداث: | Date Created: 19740801 Date Completed: 19740919 Latest Revision: 20190514 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC1343644 |
| DOI: | 10.1097/00000658-197408000-00018 |
| PMID: | 4842984 |
| قاعدة البيانات: | MEDLINE |
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