دورية أكاديمية
Beneficial effects of amiodarone pretreatment on early ischemic ventricular arrhythmias relative to infarct size and regional myocardial blood flow in the conscious dog.
| العنوان: | Beneficial effects of amiodarone pretreatment on early ischemic ventricular arrhythmias relative to infarct size and regional myocardial blood flow in the conscious dog. |
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| المؤلفون: | Chew CY, Collet JT, Campbell C, Kannan R, Singh B |
| المصدر: | Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 1982 Nov-Dec; Vol. 4 (6), pp. 1028-36. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7902492 Publication Model: Print Cited Medium: Print ISSN: 0160-2446 (Print) Linking ISSN: 01602446 NLM ISO Abbreviation: J Cardiovasc Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, Raven Press. |
| مواضيع طبية MeSH: | Amiodarone/*pharmacology , Arrhythmias, Cardiac/*physiopathology , Benzofurans/*pharmacology , Coronary Circulation/*drug effects , Coronary Disease/*physiopathology , Hemodynamics/*drug effects, Amiodarone/blood ; Animals ; Chromatography, High Pressure Liquid ; Coronary Vessels ; Dogs ; Electrocardiography ; Female ; Ligation ; Male |
| مستخلص: | The effects of chronic pretreatment with amiodarone on ischemic ventricular arrhythmias were evaluated in fully conscious instrumented dogs. In control dogs (n = 14) with large myocardial infarcts, early (first 30 min) ventricular arrhythmias occurred in a bimodal distribution with peaks at 3-5 min and at 12-25 min, with only the former associated with epicardial conduction delay. Ventricular fibrillation occurred equally frequently during each peak of early ventricular arrhythmias. Amiodarone (30 mg/kg daily) for 3-4 weeks had no significant effect (n = 11) on anatomic infarct size (28 +/- 6 vs. 30 +/- 5% of left ventricular weight) nor on collateral blood flow in the center of the infarct (19 +/- 11 vs. 15 +/- 7 ml/min/100 g of tissue) or on the ratio of endocardial/epicardial perfusion (0.23 +/- 0.19 vs. 0.28 +/- 19). Despite significant lengthening of peak epicardial conduction delay (191 +/- 20 to 239 +/- 81 ms, p less than 0.05), the frequency of early ventricular arrhythmias, especially during the second peak of ectopic activity, were markedly attenuated by amiodarone pretreatment, with the extrasystole-free intervals often being as long as 6 h. The incidence of ventricular fibrillation was 9% in the treated animals compared with 29% in the controls. In the control animals, arrhythmias always supervened when epicardial fractionation was significant, and no ectopy-free interval was present in the first 6 h following coronary occlusion. The data indicate that chronic amiodarone pretreatment exerts a beneficial effect on the frequency and severity of such ventricular tachyarrhythmias, with reduction in the incidence of ventricular fibrillation and ectopic activity in the early phases following coronary occlusion. |
| المشرفين على المادة: | 0 (Benzofurans) N3RQ532IUT (Amiodarone) |
| تواريخ الأحداث: | Date Created: 19821101 Date Completed: 19830311 Latest Revision: 20190724 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/00005344-198211000-00024 |
| PMID: | 6185768 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0160-2446 |
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| DOI: | 10.1097/00005344-198211000-00024 |