دورية أكاديمية
[Hypolipidemic action of liposome-incorporated beta-sitosterol on rats].
| العنوان: | [Hypolipidemic action of liposome-incorporated beta-sitosterol on rats]. |
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| عنوان ترانسليتريتد: | Gipolipidemicheskoe deĭstvie zakliuchennogo v liposomy beta-sitosterina u krys. |
| المؤلفون: | Mironova VN, Datsenko ZM, Kokunin VA, Kalashnikova LA |
| المصدر: | Farmakologiia i toksikologiia [Farmakol Toksikol] 1984 Jul-Aug; Vol. 47 (4), pp. 71-4. |
| نوع المنشور: | Comparative Study; English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Meditsina Country of Publication: Russia (Federation) NLM ID: 16920420R Publication Model: Print Cited Medium: Print ISSN: 0014-8318 (Print) Linking ISSN: 00148318 NLM ISO Abbreviation: Farmakol Toksikol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moscow : Izdatelstvo Meditsina |
| مواضيع طبية MeSH: | Hypolipidemic Agents/*therapeutic use , Liposomes/*administration & dosage , Sitosterols/*therapeutic use, Animals ; Cholesterol/metabolism ; Crystallization ; Drug Evaluation, Preclinical ; Hypercholesterolemia/drug therapy ; Hypercholesterolemia/metabolism ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Lipoproteins, LDL/metabolism ; Rats |
| مستخلص: | Daily administration to rats with experimental hypercholesterolemia of beta-sitosterol (5 mg/kg) contained by lecithin liposomes provoked a 25% reduction in blood plasma cholesterol in 3 weeks, whereas crystalline beta-sitosterol (50 mg/kg) produced an analogous effect in 6 weeks. The drug under study decreased the level of atherogenic beta-lipoproteins in blood plasma and intestinal mucosa, raised the content of phospholipids in blood plasma and normalized the cholesterol/phospholipid ratio. The drug high hypolipidemic activity was supported in experiments in vitro with inverted sacs of the small intestine. The drug was found to be long-acting. |
| المشرفين على المادة: | 0 (Hypolipidemic Agents) 0 (Lipoproteins, LDL) 0 (Liposomes) 0 (Sitosterols) 5LI01C78DD (gamma-sitosterol) 97C5T2UQ7J (Cholesterol) |
| تواريخ الأحداث: | Date Created: 19840701 Date Completed: 19841102 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| PMID: | 6479317 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0014-8318 |
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