دورية أكاديمية
Arthritis of hemochromatosis. Clinical spectrum, relation to histocompatibility antigens, and effectiveness of early phlebotomy.
| العنوان: | Arthritis of hemochromatosis. Clinical spectrum, relation to histocompatibility antigens, and effectiveness of early phlebotomy. |
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| المؤلفون: | Askari AD, Muir WA, Rosner IA, Moskowitz RW, McLaren GD, Braun WE |
| المصدر: | The American journal of medicine [Am J Med] 1983 Dec; Vol. 75 (6), pp. 957-65. |
| نوع المنشور: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0267200 Publication Model: Print Cited Medium: Print ISSN: 0002-9343 (Print) Linking ISSN: 00029343 NLM ISO Abbreviation: Am J Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Excerpta Medica Original Publication: New York, Donnelly. |
| مواضيع طبية MeSH: | Bloodletting*, Arthritis/*etiology , HLA Antigens/*analysis , Hemochromatosis/*diagnosis, Anti-Inflammatory Agents/therapeutic use ; Arthritis/genetics ; Arthritis/therapy ; Hemochromatosis/genetics ; Humans ; Metacarpophalangeal Joint/diagnostic imaging ; Middle Aged ; Radiography ; Vascular Surgical Procedures |
| مستخلص: | Five patients who presented with arthritis as the sole manifestation of hereditary hemochromatosis and 51 family members were studied. Studies included clinical evaluation for the presence of arthritis and hemochromatosis, roentgenography of hands, knees, and pelvis, serum iron and serum ferritin measurements, complete HLA typing for 50 of the A and B loci, and, when indicated, liver biopsy. Arthritis occurred in 45 percent of persons with hemochromatosis. Although typical involvement of second and third metacarpophalangeal joints was observed in all five patients and some family members, two with typical arthritis did not have characteristic radiographic changes, two had constitutional symptoms without arthropathy, and one had unilateral hand changes. A specific HLA haplotype (A2/B17 in Family 1 and A29/B15 in Family 2) correlated with hereditary hemochromatosis but not with the arthropathy. Phlebotomy alleviated the early constitutional symptoms but did not help advanced arthritis. Anti-inflammatory drugs, intraarticular injections of glucocorticoids, and resection osteotomies of metacarpal heads were other treatment modalities. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (HLA Antigens) |
| تواريخ الأحداث: | Date Created: 19831201 Date Completed: 19840107 Latest Revision: 20190627 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0002-9343(83)90875-6 |
| PMID: | 6650551 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0002-9343 |
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| DOI: | 10.1016/0002-9343(83)90875-6 |