دورية أكاديمية
Tocainide therapy for refractory ventricular arrhythmias.
| العنوان: | Tocainide therapy for refractory ventricular arrhythmias. |
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| المؤلفون: | Roden DM, Roden DM, Reele SB, Reele SB, Higgins SB, Higgins SB, Carr RK, Carr RK, Smith RF, Smith RF, Oates JA, Oates JA, Woosley RL, Woosley RL |
| المصدر: | American heart journal [Am Heart J] 1980 Jul; Vol. 100 (1), pp. 15-22. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print Cited Medium: Print ISSN: 0002-8703 (Print) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: St. Louis, MO : Mosby |
| مواضيع طبية MeSH: | Anilides/*therapeutic use , Arrhythmias, Cardiac/*drug therapy, Adult ; Aged ; Anilides/adverse effects ; Antibodies, Antinuclear ; Arrhythmias, Cardiac/mortality ; Dose-Response Relationship, Drug ; Female ; Heart Ventricles/physiopathology ; Humans ; Lidocaine/therapeutic use ; Male ; Middle Aged ; Tocainide |
| مستخلص: | Tocainide, a congener of lidocaine, was used to treat symptomatic ventricular arrhythmias in 19 patients resistant to or unable to tolerate conventional agents. In this highly selected group, 15 showed good initial responses to oral therapy. Ventricular tachycardia was suppressed to a greater extent than isolated ventricular ectopic depolarizations at any plasma concentration, and upward dose-ranging showed progressive suppression of both. Arrhythmia responsiveness to lidocaine was found to be an excellent predictor of tocainide response. Of the 15 responders, one died 24 hours after stopping therapy, three died while receiving tocainide, nine stopped because of adverse reactions (five allergic), and two continue on therapy at 1 and 4 years. We conclude that tocainide is an effective agent for the short-term suppression of ventricular arrhythmias, particularly ventricular tachycardia sensitive to lidocaine, but a high incidence of adverse effects limits its application to chronic therapy in many patients. |
| المشرفين على المادة: | 0 (Anilides) 0 (Antibodies, Antinuclear) 27DXO59SAN (Tocainide) 98PI200987 (Lidocaine) |
| تواريخ الأحداث: | Date Created: 19800701 Date Completed: 19800828 Latest Revision: 20190626 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0002-8703(80)90274-4 |
| PMID: | 6770666 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0002-8703 |
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| DOI: | 10.1016/0002-8703(80)90274-4 |