دورية أكاديمية
[The steroid content of the amniotic fluid in the 1st and 2nd pregnancy trimesters in 21-hydroxylase insufficiency and in fetal central nervous system defects].
| العنوان: | [The steroid content of the amniotic fluid in the 1st and 2nd pregnancy trimesters in 21-hydroxylase insufficiency and in fetal central nervous system defects]. |
|---|---|
| عنوان ترانسليتريتد: | Soderzhanie steroidov v amnioticheskoĭ zhidkosti v I i II trimestrakh beremennosti pri nedostatochnosti 21-gidroksilazy i porokakh tsentral'noĭ nervnoĭ sistema ploda. |
| المؤلفون: | Dzenis IG, Brykova EK, Zaretskaia NV, Polesterov IuA, Bakharev VA, Fanchenko ND |
| المصدر: | Akusherstvo i ginekologiia [Akush Ginekol (Mosk)] 1995 (2), pp. 23-6. |
| نوع المنشور: | Comparative Study; English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Medit︠s︡ina Country of Publication: Russia (Federation) NLM ID: 0370456 Publication Model: Print Cited Medium: Print ISSN: 0300-9092 (Print) Linking ISSN: 03009092 NLM ISO Abbreviation: Akush Ginekol (Mosk) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Medit︠s︡ina |
| مواضيع طبية MeSH: | Adrenal Hyperplasia, Congenital*/metabolism, Amniotic Fluid/*chemistry , Central Nervous System/*abnormalities , Fetal Diseases/*metabolism , Hydrocortisone/*analysis , Hydroxyprogesterones/*analysis, 17-alpha-Hydroxyprogesterone ; Biomarkers/analysis ; Female ; Humans ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Risk Factors |
| مستخلص: | A total of 103 samples of amniotic fluid obtained by transabdominal amniocentesis were examined, 52 of these from women at a high risk of giving birth to children with congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency and 30 ones with fetuses with different neural tube malformations. 17-Hydroxyprogesterone was found to be a reliable marker indicating the disease in fetuses from the group at risk of hereditary 21-OH deficiency. This marker can be effectively used as early as in the 1 gestation trimester. Fetal CNS defects are associated with hypofunction of the adrenal cortex in the II gestation trimester, observed in 60-63% of cases with hydrocephalus, anencephaly, or microcephaly. Since the function of fetal adrenals is of paramount importance for the development and maturation of a fetus, it should be examined in case of developmental defects of the neural tube, in order to predict the effect of prenatal treatment. |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Hydroxyprogesterones) 68-96-2 (17-alpha-Hydroxyprogesterone) WI4X0X7BPJ (Hydrocortisone) |
| تواريخ الأحداث: | Date Created: 19950101 Date Completed: 19950720 Latest Revision: 20161013 |
| رمز التحديث: | 20221213 |
| PMID: | 7785733 |
| قاعدة البيانات: | MEDLINE |
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