دورية أكاديمية
[Medullary carcinoma of the thyroid: a case of multiple endocrine neoplasia type 2A].
| العنوان: | [Medullary carcinoma of the thyroid: a case of multiple endocrine neoplasia type 2A]. |
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| عنوان ترانسليتريتد: | Carcinoma midollare della tiroide: un caso di neoplasia endocrina multipla tipo 2 A. |
| المؤلفون: | Pati M; Policlinico Umberto I, Università degli Studi di Roma La Sapienza, Roma., Sperti P, Magiar AV, Bonifacio V |
| المصدر: | Minerva endocrinologica [Minerva Endocrinol] 1994 Mar; Vol. 19 (1), pp. 29-32. |
| نوع المنشور: | Case Reports; English Abstract; Journal Article |
| اللغة: | Italian |
| بيانات الدورية: | Publisher: Edizioni Minerva medica Country of Publication: Italy NLM ID: 8406505 Publication Model: Print Cited Medium: Print ISSN: 0391-1977 (Print) Linking ISSN: 03911977 NLM ISO Abbreviation: Minerva Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Torino : Edizioni Minerva medica, |
| مواضيع طبية MeSH: | Adrenal Gland Neoplasms/*diagnosis , Carcinoma, Medullary/*diagnosis , Multiple Endocrine Neoplasia/*diagnosis , Pheochromocytoma/*diagnosis , Thyroid Neoplasms/*diagnosis, Adrenal Gland Neoplasms/genetics ; Biomarkers, Tumor/blood ; Calcitonin/blood ; Carcinoma, Medullary/genetics ; Humans ; Male ; Middle Aged ; Multiple Endocrine Neoplasia/genetics ; Pedigree ; Pheochromocytoma/genetics ; Thyroid Neoplasms/genetics |
| مستخلص: | Medullary thyroid carcinoma (MTC) is a neoplasm derived from thyroid C-cells. It can appear under different variants; in the 20-30% of the cases, it's a familial variant. Nevertheless, the MTC appearing in MEN 2-A has a better prognosis compared to MEN 2-B. Usually, the diagnosis of MEN 2-A is done at the age of 20, and frequently (in the 50% of the cases) these patients develop, in a second time, adrenal hyperplasia and/or pheochromocytoma. The case we are talking about, concerns a patient of 49 years old, who came to our observation with a history of bilateral adrenalectomy for pheochromocytoma. What attracted our attention was the presence, in his family, of a brother, who died from pheochromocytoma, and the mother, died for a MTC. During the admit in our section, the patient has undergone a screening for the thyroid function, also if there wasn't a sign or symptom of interest of the gland. It has been possible to single out some nodular formations that, together with the high value of the calcitonin found, allowed the diagnosis of MTC. It has been very important to make diagnosis of MEN 2-A because we can introduce the patient and his family to a program of screening to precociously single out the presence of the typical signs of this pathology. In MEN 2-A a precocious diagnosis allows to sensibly improve the prognosis. |
| Gene Symbol: | FNRB; pMCK2 |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) 9007-12-9 (Calcitonin) |
| تواريخ الأحداث: | Date Created: 19940301 Date Completed: 19940816 Latest Revision: 20151119 |
| رمز التحديث: | 20240829 |
| PMID: | 7913514 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0391-1977 |
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