دورية أكاديمية
Effects of DDAVP on renal hemodynamics and renin secretion in subjects with essential hypertension.
| العنوان: | Effects of DDAVP on renal hemodynamics and renin secretion in subjects with essential hypertension. |
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| المؤلفون: | Brink HS; Department of Internal Medicine I, Erasmus University, Rotterdam, The Netherlands., Derkx FH, Boomsma F, Schalekamp MA |
| المصدر: | Clinical nephrology [Clin Nephrol] 1994 Aug; Vol. 42 (2), pp. 95-101. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Dustri-Verlag Dr. Karl Feistle Country of Publication: Germany NLM ID: 0364441 Publication Model: Print Cited Medium: Print ISSN: 0301-0430 (Print) Linking ISSN: 03010430 NLM ISO Abbreviation: Clin Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: München-Deisenhofen, Dustri-Verlag Dr. Karl Feistle. |
| مواضيع طبية MeSH: | Deamino Arginine Vasopressin/*pharmacology , Hypertension/*physiopathology , Receptors, Vasopressin/*drug effects , Renal Circulation/*drug effects , Renin/*metabolism, Adult ; Hemodynamics/drug effects ; Humans ; Iodine Radioisotopes ; Iodohippuric Acid ; Iothalamic Acid ; Male ; Middle Aged ; Receptors, Vasopressin/physiology ; Renal Plasma Flow, Effective/drug effects |
| مستخلص: | Intravenous (i.v.) infusion of the selective vasopressin (V2) agonist 1-desamino-8-D-arginine vasopressin (DDAVP, Desmopressin) in humans causes a fall in blood pressure, an increase in heart rate, and a rise in plasma renin and noradrenaline. The present study was designed to demonstrate the vasodilatory properties of DDAVP in the renal circulation and to describe the effect of DDAVP on renin secretion. Seven male subjects (31-63 years) with hypertension, who showed no signs of renal parenchymal disease, received an i.v. infusion of DDAVP (400 ng/kg in 10 minutes). They were studied at the time they were undergoing renal vein renin sampling and renal angiography as part of the diagnostic work-up of their hypertension. 131I-Hippurate clearance was used to measure effective renal plasma flow (ERPF). True renal plasma flow was calculated as ERPF divided by the renal extraction ratio of 131I-hippurate. 125I-Thalamate clearance was used to measure glomerular filtration rate (GFR). Measurements were made before and 15-20 minutes after administration of DDAVP. Angiography was performed in the same session after the last blood samples had been collected. In all patients the renal arteries were normal and the extraction ratios of 131I-hippurate and 125I-thalamate (Ehip, Ethal) were not different for the left and right kidney, and in all seven patients a diagnosis of essential hypertension was made. After DDAVP systolic blood pressure decreased by 14.4 mmHg (2.0-26.8) (mean, 95% confidence interval, p < 0.05). Diastolic blood pressure decreased by 12.1 mmHg (2.9-21.7, p < 0.01). Heart rate increased by 17.5 bpm (11.7-23.2, p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) |
| المشرفين على المادة: | 0 (Iodine Radioisotopes) 0 (Receptors, Vasopressin) 147-58-0 (Iodohippuric Acid) 16CHD79MIX (Iothalamic Acid) EC 3.4.23.15 (Renin) ENR1LLB0FP (Deamino Arginine Vasopressin) |
| تواريخ الأحداث: | Date Created: 19940801 Date Completed: 19941216 Latest Revision: 20181130 |
| رمز التحديث: | 20221213 |
| PMID: | 7955585 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0301-0430 |
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