دورية أكاديمية
أعرض في EDS

The effects of N-methyl-D-aspartate agonists and antagonists on isolated bovine cerebral arteries.

التفاصيل البيبلوغرافية
العنوان: The effects of N-methyl-D-aspartate agonists and antagonists on isolated bovine cerebral arteries.
المؤلفون: Wendling WW; Department of Anesthesiology, Temple University Health Sciences Center, Philadelphia, Pennsylvania, USA., Chen D, Daniels FB, Monteforte MR, Fischer MB, Harakal C, Carlsson C
المصدر: Anesthesia and analgesia [Anesth Analg] 1996 Feb; Vol. 82 (2), pp. 264-8.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1310650 Publication Model: Print Cited Medium: Print ISSN: 0003-2999 (Print) Linking ISSN: 00032999 NLM ISO Abbreviation: Anesth Analg Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins
Original Publication: Cleveland, International Anesthesia Research Society.
مواضيع طبية MeSH: Cerebral Arteries/*metabolism , Excitatory Amino Acid Agonists/*pharmacology , Receptors, N-Methyl-D-Aspartate/*metabolism, Animals ; Cattle ; Cerebral Arteries/drug effects ; Cerebral Arteries/physiology ; Dextrorphan/pharmacology ; Dizocilpine Maleate/pharmacology ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/pharmacology ; Glutamates/pharmacology ; In Vitro Techniques ; Ketamine/pharmacology ; Levorphanol/pharmacology ; Potassium/pharmacology ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Thromboxane A2/pharmacology ; Vasoconstriction/drug effects ; Vasodilation/drug effects
مستخلص: This pharmacologic study examines the direct cerebrovascular effects of N-methyl-D-aspartate (NMDA) receptor agonists and antagonists to determine whether large cerebral arteries have NMDA receptors. Bovine middle cerebral arteries were cut into rings to measure isometric tension development in vitro. Two competitive agonists, L-glutamate and NMDA, each had negligible effects on ring tension in the absence of exogenous vasoconstrictors. L-glutamate (in high concentrations) produced direct relaxation of potassium (K+)-constricted arteries, but the relaxation was not selective for L-glutamate, D-glutamate, or mannitol. Relaxation with L-glutamate was abolished when it was isosmotically substituted in the K(+)-rich medium. NMDA (in the absence or presence of glycine) and two competitive antagonists, 2-amino-5-phosphopentanoic acid (AP5) and (+/-)-3-(s-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), each had little effect on the tone of arteries preconstricted with potassium or the stable thromboxane A2 analog U-46,619. Three noncompetitive antagonists (S(+)-ketamine, dizocilpine, and dextrorphan) and their steroeisomers (R(-)-ketamine, (-)MK-801, and levorphanol) each produced dose-dependent relaxation of K(+)- or U-46,619-constricted arteries; relaxation was not selective for the (+) or (-) stereoisomers. These results suggest that large cerebral arteries lack NMDA receptors mediating constriction or relaxation. All noncompetitive antagonists dilated cerebral arteries, but by mechanisms that were not stereospecific.
معلومات مُعتمدة: SO7 RR05417 United States RR NCRR NIH HHS
المشرفين على المادة: 0 (Excitatory Amino Acid Agonists)
0 (Excitatory Amino Acid Antagonists)
0 (Glutamates)
0 (Receptors, N-Methyl-D-Aspartate)
04B7QNO9WS (Dextrorphan)
27618J1N2X (Levorphanol)
57576-52-0 (Thromboxane A2)
690G0D6V8H (Ketamine)
6LR8C1B66Q (Dizocilpine Maleate)
RWP5GA015D (Potassium)
تواريخ الأحداث: Date Created: 19960201 Date Completed: 19960228 Latest Revision: 20190704
رمز التحديث: 20240829
DOI: 10.1097/00000539-199602000-00009
PMID: 8561325
قاعدة البيانات: MEDLINE
الوصف
تدمد:0003-2999
DOI:10.1097/00000539-199602000-00009