دورية أكاديمية
[Flupirtine in comparison with chlormezanone in chronic musculoskeletal back pain. Results of a multicenter randomized double-blind study].
| العنوان: | [Flupirtine in comparison with chlormezanone in chronic musculoskeletal back pain. Results of a multicenter randomized double-blind study]. |
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| عنوان ترانسليتريتد: | Flupirtin im Vergleich zu Chlormezanon und Plazebo bei chronischen muskuloskelettalen Rückenschmerzen. Ergebnisse einer multizentrischen randomisierten Doppelblindstudie. |
| المؤلفون: | Wörz R; Schmerzzentrum, Bad Schönborn., Bolten W, Heller B, Krainick JU, Pergande G |
| المصدر: | Fortschritte der Medizin [Fortschr Med] 1996 Dec 20; Vol. 114 (35-36), pp. 500-4. |
| نوع المنشور: | Clinical Trial; Comparative Study; English Abstract; Journal Article; Multicenter Study; Randomized Controlled Trial |
| اللغة: | German |
| بيانات الدورية: | Publisher: Urban Und Vogel Country of Publication: Germany NLM ID: 2984763R Publication Model: Print Cited Medium: Print ISSN: 0015-8178 (Print) Linking ISSN: 00158178 NLM ISO Abbreviation: Fortschr Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Munchen : Urban Und Vogel Original Publication: Munich, [etc.], Verlag Fortschritte der Medizin. |
| مواضيع طبية MeSH: | Aminopyridines/*administration & dosage , Analgesics/*administration & dosage , Chlormezanone/*administration & dosage , Low Back Pain/*drug therapy , Muscle Relaxants, Central/*administration & dosage , Myofascial Pain Syndromes/*drug therapy, Adult ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged |
| مستخلص: | Method: The analgesic and muscle-relaxing properties of flupirtine maleate, chlormezanone and placebo were compared in a total of 184 patients. Of these patients, 164 met the criteria of the treatment plan (intention to treat), and the data of 140 patients were finally evaluated in accordance with the test protocol. A positive response was defined as a reduction in pain intensity and muscle tension by 2 categories on the 5-category verbal scale "very severe/severe/moderate/mild/ none" on the seventh day of treatment. Results: In the per-protocol-analysis the responder rate was 60.9% for flupirtine, 47.8% for chlormezanone, and 43.8% for placebo, the difference between drugs and placebo not being significant. The overall assessment of the physicians involved was very good/ good in 47.8% and satisfactory in 37.0% of the flupirtine group, very good/good in 45.6% and satisfactory in 17.4% of the chlormezanone group, the corresponding figures for the placebo group being 33.4% and 20.6%, respectively. Flupirtine was thus superior to placebo (p = 0.007). The incidence of adverse drug reactions was 14.8% (8/54) for flupirtine, 19.3% (11/57) for chlormezanone, and 7.3% (4/55) for placebo. |
| المشرفين على المادة: | 0 (Aminopyridines) 0 (Analgesics) 0 (Muscle Relaxants, Central) GP568V9G19 (Chlormezanone) MOH3ET196H (flupirtine) |
| تواريخ الأحداث: | Date Created: 19961220 Date Completed: 19970418 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| PMID: | 9119352 |
| قاعدة البيانات: | MEDLINE |
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