دورية أكاديمية
Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E, lovastatin and amlodipine.
| العنوان: | Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E, lovastatin and amlodipine. |
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| المؤلفون: | Chen L; Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA., Haught WH, Yang B, Saldeen TG, Parathasarathy S, Mehta JL |
| المصدر: | Journal of the American College of Cardiology [J Am Coll Cardiol] 1997 Aug; Vol. 30 (2), pp. 569-75. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print Cited Medium: Print ISSN: 0735-1097 (Print) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York, N.Y.] : Elsevier Biomedical, [c1983- |
| مواضيع طبية MeSH: | Hydroxymethylglutaryl-CoA Reductase Inhibitors*, Amlodipine/*pharmacology , Anticholesteremic Agents/*pharmacology , Antioxidants/*pharmacology , Arteriosclerosis/*prevention & control , Calcium Channel Blockers/*pharmacology , Lipid Peroxidation/*drug effects , Lovastatin/*pharmacology , Vitamin E/*pharmacology, Animals ; Diet, Atherogenic ; Rabbits ; Superoxide Dismutase/metabolism |
| مستخلص: | Objectives: We sought to document the common mechanisms of the antiatherogenic effects of the cholesterol-lowering hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor lovastatin, the dihydropyridine Ca2+ blocker amlodipine and the antioxidant vitamin E. Background: Vitamin E, HMG-CoA reductase inhibitors and Ca2+ blockers each inhibit atherosclerosis in hypercholesterolemic animals. Methods: New Zealand White rabbits were fed regular chow (Group A), chow with 1% cholesterol (Group B), 1% cholesterol diet plus lovastatin (Group C), 1% cholesterol diet plus vitamin E (Group D) or 1% cholesterol diet plus amlodipine (Group E) for 12 weeks. The extent of aortic atherosclerosis was measured by planimetry of the sudanophilic area. Malondialdehyde (MDA) and superoxide dismutase (SOD) in blood were measured as indexes of lipid peroxidation and antioxidant activity, respectively. Results: Group A rabbits showed no atherosclerosis, whereas Group B rabbits had 17.4 +/- 9.3% (mean +/- SD) of the aorta covered with atherosclerosis, and Groups C, D and E rabbits had significantly less atherosclerosis. Plasma SOD activity was lower in Group B than in Group A (6.9 +/- 1.1 vs. 12.8 +/- 1.5 U/ml, p < 0.01) and was preserved in the groups given lovastatin, vitamin E or amlodipine with a high cholesterol diet. The serum MDA level was higher in Group B rabbits than Group A rabbits (12.1 +/- 2.6 vs. 1.2 +/- 0.1 nmol/ml, p < 0.01) and increased minimally in rabbits given lovastatin, vitamin E or amlodipine with a high cholesterol diet. In in vitro experiments, both lovastatin and amlodipine preserved SOD activity and reduced the oxidizability of low density lipoproteins by rabbit leukocytes. Conclusions: This study suggests that a reduction in lipid peroxidation and preservation of SOD may be common mechanisms of antiatherosclerotic effects of lovastatin, vitamin E and amlodipine. |
| المشرفين على المادة: | 0 (Anticholesteremic Agents) 0 (Antioxidants) 0 (Calcium Channel Blockers) 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) 1406-18-4 (Vitamin E) 1J444QC288 (Amlodipine) 9LHU78OQFD (Lovastatin) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 19970801 Date Completed: 19970825 Latest Revision: 20190708 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/s0735-1097(97)00158-7 |
| PMID: | 9247534 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0735-1097 |
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| DOI: | 10.1016/s0735-1097(97)00158-7 |