دورية أكاديمية
TrypTect CIATT--a card indirect agglutination trypanosomiasis test for diagnosis of Trypanosoma brucei gambiense and T. b. rhodesiense infections.
| العنوان: | TrypTect CIATT--a card indirect agglutination trypanosomiasis test for diagnosis of Trypanosoma brucei gambiense and T. b. rhodesiense infections. |
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| المؤلفون: | Nantulya VM; Brentec Diagnostics, Nairobi, Kenya. |
| المصدر: | Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 1997 Sep-Oct; Vol. 91 (5), pp. 551-3. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7506129 Publication Model: Print Cited Medium: Print ISSN: 0035-9203 (Print) Linking ISSN: 00359203 NLM ISO Abbreviation: Trans R Soc Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013- : Oxford : Oxford University Press Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene |
| مواضيع طبية MeSH: | Reagent Kits, Diagnostic* , Trypanosoma brucei gambiense* , Trypanosoma brucei rhodesiense*, Trypanosomiasis, African/*diagnosis, Agglutination Tests/methods ; Animals ; Antigens, Protozoan/blood ; Humans ; Mice ; Predictive Value of Tests ; Sensitivity and Specificity ; Serologic Tests |
| مستخلص: | A simple and rapid test, the card indirect agglutination trypanosomiasis test (TrypTect CIATT) is described, for detecting circulating antigens in persons suffering from Trypanosoma brucei gambiense and T. b. rhodesiense infection by latex agglutination. The sensitivity of the test (95.8% for T. b. gambiense and 97.7% for T. b. rhodesiense) was significantly higher than that of lymph node puncture, microhaematocrit centrifugation and cerebrospinal fluid examination after single and double centrifugation. The specificity of the test was also high: 106 blood donor sera as well as sera from 37 patients with malaria, 25 with visceral leishmaniasis, 10 with schistosomiasis, 5 with filariasis and 10 with hydatid disease, from trypanosomiasis-free areas, gave negative results. Eighteen clinical suspects from active disease transmission foci, without microscopically detectable parasitaemia but with a positive test result, were further examined by lumbar puncture and inoculation of blood into mice; 11 (61%) were found to be infected, suggesting that the test had a high positive predictive value. This study showed that TrypTect CIATT is a useful test for rapid diagnosis of both patent and non-patent T. b. gambiense and T. b. rhodesiense infections. |
| المشرفين على المادة: | 0 (Antigens, Protozoan) 0 (Reagent Kits, Diagnostic) |
| تواريخ الأحداث: | Date Created: 19980217 Date Completed: 19980226 Latest Revision: 20190512 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/s0035-9203(97)90023-7 |
| PMID: | 9463665 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0035-9203 |
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| DOI: | 10.1016/s0035-9203(97)90023-7 |