دورية أكاديمية
Multiple protein-binding sites in the TAS-region of human and rat mitochondrial DNA.
| العنوان: | Multiple protein-binding sites in the TAS-region of human and rat mitochondrial DNA. |
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| المؤلفون: | Roberti M; Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, Italy., Musicco C, Polosa PL, Milella F, Gadaleta MN, Cantatore P |
| المصدر: | Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1998 Feb 04; Vol. 243 (1), pp. 36-40. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print Cited Medium: Print ISSN: 0006-291X (Print) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002- >: San Diego, CA : Elsevier Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | DNA, Mitochondrial/*genetics , DNA, Mitochondrial/*metabolism, Animals ; Base Sequence ; Binding Sites/genetics ; Cattle ; DNA Footprinting ; DNA, Mitochondrial/chemistry ; DNA-Binding Proteins/metabolism ; Humans ; Molecular Sequence Data ; Protein Binding ; Rats ; Species Specificity |
| مستخلص: | To study the molecular mechanisms responsible for the regulation of mitochondrial DNA copy number, in vivo and in organello dimethyl sulfate footprinting experiments in human fibroblasts and rat liver mitochondria were carried out. By this approach we identified in both species two specific protein binding sites in the 3' region of the displacement loop of mitochondrial DNA. One site contains the TAS-D element of human and rat mitochondrial DNA; the other covers TAS-C and TAS-B in human, whereas in rat it comprises part of TAS-B. We suggest that the protected sequences might be the site of action of protein factors involved in the premature termination of mitochondrial DNA heavy-strand synthesis. |
| معلومات مُعتمدة: | 863 Italy TI_ Telethon |
| المشرفين على المادة: | 0 (DNA, Mitochondrial) 0 (DNA-Binding Proteins) |
| تواريخ الأحداث: | Date Created: 19980225 Date Completed: 19980316 Latest Revision: 20220129 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1006/bbrc.1997.8052 |
| PMID: | 9473475 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0006-291X |
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| DOI: | 10.1006/bbrc.1997.8052 |