دورية أكاديمية
T cell precursors in man and mice.
| العنوان: | T cell precursors in man and mice. |
|---|---|
| المؤلفون: | Blom B; Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam, The Netherlands., Res PC, Spits H |
| المصدر: | Critical reviews in immunology [Crit Rev Immunol] 1998; Vol. 18 (4), pp. 371-88. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Begell House Country of Publication: United States NLM ID: 8914819 Publication Model: Print Cited Medium: Print ISSN: 1040-8401 (Print) Linking ISSN: 10408401 NLM ISO Abbreviation: Crit Rev Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Begell House Original Publication: Boca Raton, Fla. : CRC Press, c1980- |
| مواضيع طبية MeSH: | Hematopoietic Stem Cells/*immunology , T-Lymphocytes/*immunology, Animals ; Hematopoietic Stem Cells/cytology ; Humans ; Mice ; T-Lymphocytes/cytology |
| مستخلص: | The thymus is seeded at week 7-8 of gestation with hematopoietic progenitor cells derived from the liver. By week 15-16 of gestation a fully differentiated thymus with a cortical/medullary junction and Hassal's corpuscles has been formed. The thymus is continuously populated by progenitor cells first from the liver and then from bone marrow. This process continues in childhood after which the thymus starts to involute. Recent information indicates that the cells that populate the thymus are not committed to the T cell lineage. When developing to T cells these progenitor cells traverse a series of cellular stages that can be discriminated on the basis of cell surface and cytoplasmic markers, status of TCR gene rearrangements and precursor cell activities. The early stages of T cell development in the mouse thymus have been described in detail. The recent development of assays to measure the T cell precursor activity of human thymic and extrathymic progenitor cell subsets has led to a rapid accumulation of data on early events in human thymic development as well. The information available now permits a comparison of early cellular stages of T cell development in mice and man. Some of the extrinsic and intrinsic factors that govern T cell differentiation will be discussed. Data on the role of the cytokine, interleukin-7, in human and mouse T cell development will be summarized. Furthermore, recent data on the involvement of transcription factors in early T cell development are reviewed. |
| Number of References: | 155 |
| تواريخ الأحداث: | Date Created: 19980815 Date Completed: 19981106 Latest Revision: 20191102 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1615/critrevimmunol.v18.i4.50 |
| PMID: | 9704195 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1040-8401 |
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| DOI: | 10.1615/critrevimmunol.v18.i4.50 |