دورية أكاديمية
Nebulized magnesium sulphate versus nebulized salbutamol in acute bronchial asthma: a clinical trial.
| العنوان: | Nebulized magnesium sulphate versus nebulized salbutamol in acute bronchial asthma: a clinical trial. |
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| المؤلفون: | Mangat HS; Dept of Medicine, St John's Medical College Hospital, St John's National Academy of Health Sciences, Bangalore, Karnataka, India., D'Souza GA, Jacob MS |
| المصدر: | The European respiratory journal [Eur Respir J] 1998 Aug; Vol. 12 (2), pp. 341-4. |
| نوع المنشور: | Clinical Trial; Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Print Cited Medium: Print ISSN: 0903-1936 (Print) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sheffield, United Kingdom : European Respiratory Society Original Publication: Copenhagen : Published jointly by the Society and Munksgaard, 1988- |
| مواضيع طبية MeSH: | Albuterol/*administration & dosage , Asthma/*drug therapy , Bronchodilator Agents/*administration & dosage , Magnesium Sulfate/*administration & dosage, Administration, Inhalation ; Adult ; Aerosols ; Albuterol/therapeutic use ; Bronchodilator Agents/therapeutic use ; Double-Blind Method ; Female ; Humans ; Magnesium Sulfate/therapeutic use ; Male ; Nebulizers and Vaporizers |
| مستخلص: | Intravenous magnesium sulphate (MgSO4) has successfully been used in the treatment of acute asthma. The present study investigated the efficacy of nebulized MgSO4 as a bronchodilator in acute asthma as compared to nebulized salbutamol. This was a randomized, double-blind, controlled clinical trial. Asthmatics aged 12-60 yrs in acute exacerbation, with a peak expiratory flow (PEF) <300 L x min(-1), not having taken bronchodilators and not requiring assisted ventilation were included. Patients were randomized to receive treatment with serial nebulizations of either 3 mL (3.2% solution, 95 mg) MgSO4 solution or 3 mL (2.5 mg) salbutamol solution. All patients were also given 100 mg hydrocortisone i.v., and were monitored continuously for 2 h after which they were given supplemental treatment (if and when needed) and either discharged or admitted. Fischl index, PEF improvements (in % predicted) and admission rates were the outcome variables. Thirty-three patients were studied. Fischl score improvement was comparable and significant in both groups (4.31 to 0.43 in the MgSO4 group and 4.29 to 0.76 in the salbutamol group). The increase in PEF was statistically significant and comparable in both groups (by 35% pred in the MgSO4 and by 42% pred in the salbutamol group). Two patients warranted admission in the salbutamol group and one in the MgSO4 group. Nebulized MgSO4 had a significant bronchodilatory effect in acute asthma. This effect was not significantly different from that of nebulized salbutamol. |
| المشرفين على المادة: | 0 (Aerosols) 0 (Bronchodilator Agents) 7487-88-9 (Magnesium Sulfate) QF8SVZ843E (Albuterol) |
| تواريخ الأحداث: | Date Created: 19980904 Date Completed: 19981120 Latest Revision: 20190822 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1183/09031936.98.12020341 |
| PMID: | 9727782 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0903-1936 |
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| DOI: | 10.1183/09031936.98.12020341 |