دورية أكاديمية
Increased mortality after successful treatment for Hodgkin's disease.
| العنوان: | Increased mortality after successful treatment for Hodgkin's disease. |
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| المؤلفون: | Hudson MM; Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. melissa.hudson@stjude.org, Poquette CA, Lee J, Greenwald CA, Shah A, Luo X, Thompson EI, Wilimas JA, Kun LE, Crist WM |
| المصدر: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 1998 Nov; Vol. 16 (11), pp. 3592-600. |
| نوع المنشور: | Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print Cited Medium: Print ISSN: 0732-183X (Print) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Alexandria, VA : American Society of Clinical Oncology Original Publication: New York, N.Y. : Grune & Stratton, c1983- |
| مواضيع طبية MeSH: | Hodgkin Disease/*mortality, Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Child ; Child, Preschool ; Cohort Studies ; Disease Progression ; Female ; Heart Diseases/mortality ; Hodgkin Disease/therapy ; Humans ; Infections/mortality ; Male ; Neoplasms, Second Primary/mortality ; Radiotherapy/adverse effects ; Recurrence ; Risk Factors ; Time Factors |
| مستخلص: | Purpose: To determine the impact of treatment toxicity on long-term survival in pediatric Hodgkin's disease. Patients and Methods: We studied late events in 387 patients treated for pediatric Hodgkin's disease on four consecutive clinical trials at St Jude Children's Research Hospital from 1968 to 1990. Relative risks, actuarial risks, and absolute excess risks for cause-specific deaths were calculated. Results: As of April 1997, 316 (82%) of patients were alive, with a median follow-up of 15.1 (range, 2.9 to 28.6) years. In this cohort, which represented 5,623 person-years of follow-up, 71 fatal events resulted from Hodgkin's disease (n=36), second malignancies (n=14), infections (n=7), accidents (n=7), cardiac disease (n=6), and asphyxiation (n=1). The 5-year estimated event-free survival (EFS) for the entire cohort was 79.6%+/-2.1 %, which declined to 63.1%+/-4.4% by 20 years. Cumulative incidences of cause-specific deaths at 25 years were 9.8%+/-1.6% for Hodgkin's disease, 8.1%+/-2.6% for second malignancy, 4.0%+/-1.8% for cardiac disease, 3.9%+/-1.5% for infection, and 2.1%+/-0.8% for accidents. Standardized incidence ratios showed excess risk for all second malignancies (12; 95% confidence interval [CI], 8 to 17), acute myeloid leukemia (81; 95% CI, 16 to 237), solid tumors (11; 95% CI, 7 to 16), and breast cancer (33; 95% CI, 12 to 72). Standardized mortality ratios also showed excess mortality from cardiac disease (22; 95% CI, 8 to 48) and infection (18; 95% CI, 7 to 38). Conclusion: Compared with age- and sex-matched control populations, survivors of pediatric Hodgkin's disease who were treated before 1990 face an increased risk of early mortality related to second cancers, cardiac disease, and infection. |
| معلومات مُعتمدة: | CA-20180 United States CA NCI NIH HHS; CA-21765 United States CA NCI NIH HHS; CA-23099 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 19981117 Date Completed: 19981130 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1200/JCO.1998.16.11.3592 |
| PMID: | 9817280 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0732-183X |
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| DOI: | 10.1200/JCO.1998.16.11.3592 |