دورية أكاديمية
Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: implications for risk assessment.
| العنوان: | Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: implications for risk assessment. |
|---|---|
| المؤلفون: | Goldstein LS; Electric Power Research Institute, Palo Alto, CA 94303, USA. lgoldste@epri.com, Weyand EH, Safe S, Steinberg M, Culp SJ, Gaylor DW, Beland FA, Rodriguez LV |
| المصدر: | Environmental health perspectives [Environ Health Perspect] 1998 Dec; Vol. 106 Suppl 6, pp. 1325-30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Print ISSN: 0091-6765 (Print) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences. |
| مواضيع طبية MeSH: | Benzo(a)pyrene/*toxicity , Carcinogens/*toxicity , Coal Tar/*toxicity , DNA Adducts/*drug effects, Administration, Oral ; Animals ; Carcinogenicity Tests ; Drug Interactions ; Female ; Injections, Intraperitoneal ; Mice ; Mice, Inbred Strains ; Risk Assessment ; Time Factors |
| مستخلص: | Current methods to estimate the quantitative cancer risk of complex mixtures of polycyclic aromatic hydrocarbons (PAH) such as coal tar assume that overall potency can be derived from knowledge of the concentration of a few carcinogenic components such as benzo[a]pyrene (B[a]P). Genotoxic damage, such as DNA adducts, is thought to be an essential aspect of PAH-induced tumorigenesis and could be a biomarker for exposure useful for estimating risk. However, the role of B[a]P and the relationship of adduct formation in tumorigenesis have not been tested rigorously in models appropriate for human health risk assessment. Therefore, we directly compared tumor induction and adduct formation by B[a]P and coal tars in several experimental protocols, including one broadly accepted and used by regulators. We found that B[a]P content did not account for tumor incidences after exposure to coal tars. DNA adducts were found in both tumors and tumor-free tissue and tumor outcomes were not predicted by either quantitation of total DNA adducts or by the DNA adduct formed by B[a]P. These data suggest that risk assessments based on B[a]P content may not predict accurately risk to human health posed by environmental PAH. |
| References: | Carcinogenesis. 1994 Feb;15(2):247-52. (PMID: 8313515) J Toxicol Environ Health. 1994 May;42(1):89-107. (PMID: 8169998) Carcinogenesis. 1994 Dec;15(12):2835-40. (PMID: 8001243) Chem Biol Interact. 1995 Jun 14;96(3):207-21. (PMID: 7750161) Chem Res Toxicol. 1995 Oct-Nov;8(7):949-54. (PMID: 8555410) Circ Res. 1992 May;70(5):991-8. (PMID: 1568306) Carcinogenesis. 1997 Jan;18(1):127-35. (PMID: 9054599) Carcinogenesis. 1998 Jan;19(1):117-24. (PMID: 9472702) Tex Rep Biol Med. 1967 Winter;25(4):553-7. (PMID: 6082228) J Natl Cancer Inst. 1983 Sep;71(3):539-44. (PMID: 6577228) Cancer Lett. 1987 Jan;34(1):49-54. (PMID: 3802069) Chem Res Toxicol. 1995 Oct-Nov;8(7):955-62. (PMID: 8555411) |
| المشرفين على المادة: | 0 (Carcinogens) 0 (DNA Adducts) 3417WMA06D (Benzo(a)pyrene) 8007-45-2 (Coal Tar) |
| تواريخ الأحداث: | Date Created: 19981223 Date Completed: 19990420 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC1533461 |
| DOI: | 10.1289/ehp.98106s61325 |
| PMID: | 9860888 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0091-6765 |
|---|---|
| DOI: | 10.1289/ehp.98106s61325 |