التفاصيل البيبلوغرافية
| العنوان: |
Essential roles of bile acid receptors FXR and TGR5 as metabolic regulators. |
| المؤلفون: |
Jacinto, Sandra, Fang, Sungsoon |
| المصدر: |
Animal Cells & Systems; Dec2014, Vol. 18 Issue 6, p359-364, 6p |
| مصطلحات موضوعية: |
FARNESOID X receptor, METABOLIC regulation, BILE acids, TYPE 2 diabetes, G protein coupled receptors, ENERGY metabolism |
| مستخلص: |
Alterations of bile acid (BA) metabolism in type II diabetes (T2D) have revealed a link between BAs and metabolic homeostasis. The BA receptors farnesoid X receptor (FXR) and G-protein coupled BA receptor 1 (TGR5) both have shown to regulate lipid, glucose, and energy metabolism, rendering them potential therapeutic targets for T2D therapy. Astonishingly, BA signaling is vital as it has known to be a positive factor for beneficial improvements in vertical sleeve gastrectomy surgery, in turn making these BA receptors beneficial tools in therapeutic targets for T2D. These metabolic regulators: FXR and TGR5 are essential modulators in the metabolic system, which affect the human machinery and will be the focus of this review. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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