دورية أكاديمية
Expression of MET in alveolar soft part sarcoma.
| العنوان: | Expression of MET in alveolar soft part sarcoma. |
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| المؤلفون: | Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Yoo KH, Choi YL, Jun, Hyun Jung, Lee, Jeeyun, Lim, Do Hyoung, Park, Joon Oh, Ahn, Geunghwan, Seo, Sung Wook, Sung, Ki-Sun, Lim, Do Hoon, Yoo, Keon Hee, Choi, Yoon-La |
| المصدر: | Medical Oncology; Jun2010, Vol. 27 Issue 2, p459-465, 7p |
| مستخلص: | Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma which is characterized by the presence of a specific chromosomal translocation encoding the chimeric transcription factor (ASPL-TFE3) that activates expression of MET. We reviewed the clinical features and treatment outcome of 12 ASPS patients. The presence of ASPL-TFE3 fusion transcripts was assessed by reverse transcriptase polymerase chain reaction. In addition, we performed immunohistochemical studies for MET, TFE3, Ki-67, and EGFR expression. Lower extremity was the most commonly affected primary site (2 thigh, 3 lower leg, and 1 foot). Of four patients who received primary cytotoxic chemotherapy, no patient demonstrated treatment response. With follow-up duration of 94.4 months, median overall survival was 53.2 (95% C.I. 40.9-65.5) months. The immunohistochemical staining demonstrated 100% TFE3 positivity (8 of 8), 75% MET positivity (6 of 8) with a strong association between TFE3 expression and MET positivity with correlation coefficient of 0.808 (P = 0.02). The high expression of MET in ASPL-TFE3 (+) ASPS may further support the potential role of targeted agents against MET in this rare, chemoresistant tumor. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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