دورية أكاديمية
Hippocampal spine changes across the sleep-wake cycle: corticosterone and kinases.
| العنوان: | Hippocampal spine changes across the sleep-wake cycle: corticosterone and kinases. |
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| المؤلفون: | Muneki Ikeda, Yasushi Hojo, Yoshimasa Komatsuzaki, Masahiro Okamoto, Asami Kato, Taishi Takeda, Suguru Kawato |
| المصدر: | Journal of Endocrinology; Aug2015, Vol. 226 Issue 2, pM13-M27, 15p |
| مصطلحات موضوعية: | CORTICOSTERONE, CIRCADIAN rhythms, HIPPOCAMPUS (Brain), LABORATORY rats, SLEEP-wake cycle, WAKEFULNESS, DROWSINESS, CEREBROSPINAL fluid |
| مستخلص: | The corticosterone (CORT) level changes along the circadian rhythm. Hippocampus is sensitive toCORT, since glucocorticoidreceptors are highly expressed. Inrathippocampus fixedin a living state every 3 h, we found that the dendritic spine density of CA1 pyramidal neurons increased uponwaking(within 3 h), as comparedwiththe spine density in the sleep state. Particularly, the large-headspines increased. The observed change in the spinedensity may bedue to the change in the hippocampal CORT level, since the CORT level at awake state (~30 nM) in cerebrospinal fluid was higher than that at sleep state (~3 nM), as observed from our earlier study. In adrenalectomized (ADX) rats, such a wake-induced increase of the spine density disappeared. S.c. administration of CORT intoADX rats rescued the decreased spine density. By using isolated hippocampal slices, we found that the application of 30 nM CORT increased the spine density within 1 h and that the spine increase was mediated via PKA, PKC, ERK MAPK, and LIMK signaling pathways. These findings suggest that the moderately rapid increase of the spine density on waking might mainly be caused by the CORT-driven kinase networks. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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