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Resveratrol Reduces Morphologic Changes in the Myenteric Plexus and Oxidative Stress in the Ileum in Rats with Ischemia/Reperfusion Injury.

التفاصيل البيبلوغرافية
العنوان: Resveratrol Reduces Morphologic Changes in the Myenteric Plexus and Oxidative Stress in the Ileum in Rats with Ischemia/Reperfusion Injury.
المؤلفون: Silva de Souza, Aline, Borges, Stephanie, Beraldi, Evandro, Sá-Nakanishi, Anacharis, Comar, Jurandir, Bracht, Adelar, Natali, Maria, Buttow, Nilza, da Silva de Souza, Aline Cristine, Borges, Stephanie Carvalho, Beraldi, Evandro José, de Sá-Nakanishi, Anacharis Babeto, Comar, Jurandir Fernando, Natali, Maria Raquel Marçal, Buttow, Nilza Cristina
المصدر: Digestive Diseases & Sciences; Nov2015, Vol. 60 Issue 11, p3252-3263, 12p
مصطلحات موضوعية: ILEUM innervation, ANIMAL experimentation, ANTIOXIDANTS, AUTONOMIC nervous system, BIOLOGICAL models, GLUTATHIONE, ILEUM, ILEUM diseases, LIPID peroxidation (Biology), NEURONS, ORAL drug administration, OXIDOREDUCTASES, RATS, REPERFUSION injury, STILBENE, OXIDATIVE stress, NEUROPROTECTIVE agents, PHARMACODYNAMICS
مستخلص: Background: Intestinal ischemia/reperfusion injury can be caused by surgical procedures and inflammatory bowel disease. It is normally associated with the increased production of free radicals and changes in the enteric nervous system.Aims: Given the antioxidant and neuroprotective properties of resveratrol, the present study assessed its influence on oxidative stress in the intestinal wall and the morphology of myenteric neurons in the ileum of rats subjected to ischemia/reperfusion.Methods: Resveratrol was orally administered daily at a dose of 10 mg/kg for 5 days. Changes in the ileum response to ischemia after 45 min were investigated followed by 3 h reperfusion. Lipoperoxide and carbonylated protein levels, and the activity of the antioxidant enzymes glutathione reductase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase were measured following ischemia/reperfusion injury.Results: The density and morphometry of the general neuronal population, nitrergic neurons and glial cells, and morphometry of VIP varicosities in the ileum were also studied. Lipoperoxide and carbonylated protein levels were 171 and 40% higher during the ischemia/reperfusion, respectively, compared to control cohorts, and resveratrol attenuated these values. The glutathione ratio was 64% lower during ischemia/reperfusion, compared to control cohorts. Resveratrol increased the reduced/oxidized glutathione ratio, attenuated the changes in the activity of the antioxidant enzymes and the detrimental morphologic changes caused by ischemia/reperfusion in the general neuronal population and nitrergic neurons.Conclusions: Oral treatment with resveratrol reduced the oxidative stress in the ileum and attenuated the morphologic changes that occurred in the myenteric plexus of the ileum in rats subjected to ischemia/reperfusion. [ABSTRACT FROM AUTHOR]
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قاعدة البيانات: Complementary Index
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