التفاصيل البيبلوغرافية
| العنوان: |
Zygophyllum gaetulum attenuates hypercholesterolemia and protects against oxidative stress in rats fed a high-cholesterol diet. |
| المؤلفون: |
Berzou, Sadia, Taleb-Senouci, Douja, Guenzet, Akila, Krouf, Djamil |
| المصدر: |
Journal of Experimental & Integrative Medicine; Oct-Dec2014, Vol. 4 Issue 4, p255-260, 6p |
| مصطلحات موضوعية: |
ZYGOPHYLLACEAE, HYPERCHOLESTEREMIA, OXIDATIVE stress |
| مستخلص: |
Objective: The purpose of this study was to investigate the possible protective effects of Zygophyllum gaetulum (Zg) aqueous extract on hypercholesterolemia (HC) and oxidative stress in rats fed a high-cholesterol diet. Materials and Methods: Twelve HC rats were divided into two groups fed a 20% casein diet enriched with 1% cholesterol + 0.5% cholic acid and supplemented (HC-Zg) or not (HC) with Zg extract (1%), for 4 weeks. Results: In the HC-Zg group compared with the HC group, plasma total cholesterol and low density lipoprotein cholesterol concentrations were respectively 1.5- and 2.4-fold lower, whereas high-density lipoprotein cholesterol levels were higher (+50%). Thiobarbituric acid reactive substances (TBARS) concentrations were decreased in plasma (-76%). Moreover, TBARS concentrations were respectively 4-, 3.2-, 1.8- and 3.4-fold lower in liver, heart, brain and aorta. Superoxide dismutase activity was respectively 4- and 1.2-fold higher in liver and aorta. Increased catalase (CAT) activity was noted in liver (+14%), heart (+27%) and aorta (+17%), while glutathione peroxidase (GSH-Px) activity was respectively 2.3- and 1.6-fold higher in liver and aorta. An important glutathione reductase (GR) activity was noted in heart (+14%), brain (+47%) and aorta (+23%). Reduced GSH levels were respectively increased by 78, 35 and 65% in liver, heart and aorta. Conclusion: These results show that Zg aqueous extract improves HC and oxidative stress induced by a high cholesterol diet and consequently may protect against cardiovascular diseases. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
