التفاصيل البيبلوغرافية
| العنوان: |
Possible Mechanism of Action of the Antiallergic Effect of an Aqueous Extract of Heliotropium indicum L. in Ovalbumin-Induced Allergic Conjunctivitis. |
| المؤلفون: |
Kyei, Samuel, Koffuor, George Asumeng, Ramkissoon, Paul, Abokyi, Samuel, Owusu-Afriyie, Osei, Wiredu, Eric Addo |
| المصدر: |
Journal of Allergy; 11/10/2015, p1-7, 7p |
| مصطلحات موضوعية: |
BIOCHEMICAL mechanism of action, ANTIALLERGIC agents, HELIOTROPIUM, ALLERGIC conjunctivitis, OVALBUMINS, IMMUNOREGULATION, IMMUNOSUPPRESSION, ALLERGY treatment |
| مصطلحات جغرافية: |
GHANA |
| مستخلص: |
Heliotropium indicum is used traditionally as a remedy for conjunctivitis in Ghana. This study therefore evaluated the antiallergic potential of an aqueous whole plant extract of Heliotropium indicum (HIE) in ovalbumin-induced allergic conjunctivitis and attempted to predict its mode of action. Clinical scores for allergic conjunctivitis induced by intraperitoneal ovalbumin sensitization (100 : 10 μg OVA/Al(OH)3 in phosphate-buffered saline [PBS]) and topical conjunctival challenge (1.5 mg OVA in 10 μL PBS) in Dunkin-Hartley guinea pigs were estimated after a week’s daily treatment with 30–300 mg kg−1 HIE, 30 mg kg−1 prednisolone, 10 mg kg−1 chlorpheniramine, or 10 mL kg−1 PBS. Ovalbumin-specific IgG and IgE and total IgE in serum were estimated using Enzyme-Linked Immunosorbent Assay. Histopathological assessment of the exenterated conjunctivae was also performed. The 30 and 300 mg kg−1 HIE treatment resulted in a significantly (p≤0.001) low clinical score of allergic conjunctivitis. Ovalbumin-specific IgG and IgE as well as total serum IgE also decreased significantly (p≤0.01–0.001). The conjunctival tissue in HIE treated guinea pigs had mild mononuclear infiltration compared to the PBS-treated ones, which had intense conjunctival tissue inflammatory infiltration. HIE exhibited antiallergic effect possibly by immunomodulation or immunosuppression. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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