التفاصيل البيبلوغرافية
| العنوان: |
Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis. |
| المؤلفون: |
Xueping Chen, Yongping Chen, Qianqian Wei, Ruwei Ou, Bei Cao, Bi Zhao, Hui-Fang Shang, Chen, Xueping, Chen, Yongping, Wei, Qianqian, Ou, Ruwei, Cao, Bei, Zhao, Bi, Shang, Hui-Fang |
| المصدر: |
BMC Neurology; 9/15/2016, Vol. 16, p1-7, 7p, 2 Charts, 2 Graphs |
| مصطلحات موضوعية: |
BIOMARKERS, AMYOTROPHIC lateral sclerosis treatment, AMYOTROPHIC lateral sclerosis, NEUROLOGICAL disorders, LOGISTIC regression analysis, PATIENTS, CALCIUM-binding proteins, GLYCOSIDASES, NERVE tissue proteins, PHOSPHORYLATION, PROTEINS, PREDICTIVE tests, CASE-control method, DISEASE progression, DIAGNOSIS |
| مستخلص: |
Background: The aim of the study was to assess a panel of promising biomarkers for their ability to improve diagnosis of sporadic amyotrophic lateral sclerosis (ALS).Methods: Forty patients with sporadic ALS and 40 controls with other neurological diseases were evaluated. Levels of phosphorylated neurofilament heavy chain (pNfH), S100-β, cystatin C, and chitotriosidase (CHIT) in cerebrospinal fluid were assayed using two-site solid-phase sandwich ELISA.Results: Patients with sporadic ALS showed higher levels of pNfH and CHIT than controls, but lower levels of cystatin C. Multivariate logistic regression that adjusted for patient age and sex identified significant associations between sporadic ALS and levels of pNfH, CHIT and cystatin C. Levels of pNfH correlated positively with rate of progression and decline based on the Amyotrophic Lateral Sclerosis Functional Rating Scale - Revised. Based on receiver operating curve analysis, a pNfH cut-off of 437 ng/L discriminated patients from controls with a sensitivity of 97.3 % and specificity of 83.8 %. A CHIT cut-off of 1593.779 ng/L discriminated patients from controls with a sensitivity of 83.8 % and specificity of 81.1 %. Combining the two biomarkers gave a sensitivity of 83.8 % and specificity of 91.9 %.Conclusions: Levels of pNfH in cerebrospinal fluid may be a reliable biomarker for diagnosing ALS, and combining this biomarker with levels of CHIT may improve diagnostic accuracy. [ABSTRACT FROM AUTHOR] |
|
Copyright of BMC Neurology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder