دورية أكاديمية
Comparative pharmacokinetics of rVIII-SingleChain and octocog alfa (Advate®) in patients with severe haemophilia A.
العنوان: | Comparative pharmacokinetics of rVIII-SingleChain and octocog alfa (Advate®) in patients with severe haemophilia A. |
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المؤلفون: | Klamroth, R., Simpson, M., Depka ‐ Prondzinski, M., Gill, J. C., Morfini, M., Powell, J. S., Santagostino, E., Davis, J., Huth ‐ Kühne, A., Leissinger, C., Neumeister, P., Bensen ‐ Kennedy, D., Feussner, A., Limsakun, T., Zhou, M., Veldman, A., St. Ledger, K., Blackman, N., Pabinger, I. |
المصدر: | Haemophilia; Sep2016, Vol. 22 Issue 5, p730-738, 9p, 1 Illustration, 4 Charts, 1 Graph |
مصطلحات موضوعية: | HEMOPHILIA treatment, BLOOD coagulation factor VIII antibodies, PHARMACOKINETICS, HEMOPHILIACS, RECOMBINANT antibodies, MEDICAL care |
مستخلص: | Background rVIII-SingleChain, a novel recombinant factor VIII ( rFVIII), has been designed as a B-domain truncated construct with covalently bonded heavy and light chains, aiming to increase binding affinity to von Willebrand factor (VWF). Preclinical studies confirmed greater affinity for VWF, giving improved pharmacokinetic and pharmacodynamic properties compared with full-length rFVIII. Aim To investigate the pharmacokinetics of rVIII-SingleChain and compare them against those of full-length rFVIII. Methods This study enrolled 27 patients with severe haemophilia A in the AFFINITY clinical trial programme. After a 4-day washout period, all patients received a single infusion of 50 IU kg−1 octocog alfa (Advate®); after a ≥4-day postinfusion washout period, they received a single infusion of 50 IU kg−1 rVIII-SingleChain. Blood samples for pharmacokinetic assessments of each product were collected before infusion (predose) and at 0.5, 1, 4, 8, 10, 24, 32, 48 and 72 h postinfusion for both products. Results rVIII-SingleChain had a longer mean half-life ( t |
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قاعدة البيانات: | Complementary Index |
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